发明公开
EP1804786A2 SUBSTITUTED N-ARYL-9-OXO-9H-FLUORENE-1-CARBOXAMIDES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS
审中-公开
取代的N-芳基-9-氧代-9H-芴-1-羧酰胺和胱天蛋白酶和凋亡触发器的类似物作为资产GATES
- 专利标题： SUBSTITUTED N-ARYL-9-OXO-9H-FLUORENE-1-CARBOXAMIDES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS
- 专利标题（中）： 取代的N-芳基-9-氧代-9H-芴-1-羧酰胺和胱天蛋白酶和凋亡触发器的类似物作为资产GATES
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申请号： EP05802540.4申请日： 2005-09-29
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公开(公告)号： EP1804786A2公开(公告)日： 2007-07-11
- 发明人: KEMNITZER, Wiliam, E. , CAI, Sui Xiong , DREWE, John, A. , SIRISOMA, Nilantha, Sudath
- 申请人： Cytovia, Inc.
- 申请人地址： 6650 Nancy Ridge Drive San Diego, CA 92121 US
- 专利权人： Cytovia, Inc.
- 当前专利权人： Cytovia, Inc.
- 当前专利权人地址： 6650 Nancy Ridge Drive San Diego, CA 92121 US
- 代理机构： Schlich, George William
- 优先权： US613817P 20040929
- 国际公布： WO2006039356 20060413
- 主分类号： A61K31/34
- IPC分类号： A61K31/34 ; A61K31/38 ; A61K31/40 ; A61K31/165
摘要：
The present invention is directed to substituted N-aryl-9-oxo-9H-fluorene-1-carboxamides and analogs thereof, represented by the general Formula I: (I) wherein R1-R8, X and Ar are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
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