专利检索 ap:("Cytovia, Inc.") AND inv:"KEMNITZER, Wiliam, E." 第 1 页

1.

发明公开
SUBSTITUTED N-ARYL-9-OXO-9H-FLUORENE-1-CARBOXAMIDES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS 审中-公开
标题翻译：取代的N-芳基-9-氧代-9H-芴-1-羧酰胺和胱天蛋白酶和凋亡触发器的类似物作为资产GATES

公开(公告)号：EP1804786A2

公开(公告)日：2007-07-11

申请号：EP05802540.4

申请日：2005-09-29

申请人： Cytovia, Inc.

发明人： KEMNITZER, Wiliam, E. , CAI, Sui Xiong , DREWE, John, A. , SIRISOMA, Nilantha, Sudath

IPC分类号： A61K31/34 , A61K31/38 , A61K31/40 , A61K31/165

CPC分类号： C07D209/88 , A61K31/165 , A61K31/167 , A61K31/343 , A61K31/381 , A61K31/403

摘要： The present invention is directed to substituted N-aryl-9-oxo-9H-fluorene-1-carboxamides and analogs thereof, represented by the general Formula I: (I) wherein R1-R8, X and Ar are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.