发明公开
EP1804794A2 SPIROPIPERIDINE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHERMER S DISEASE
有权
螺哌啶化合物作为阿尔茨海默氏病的治疗β-分泌酶抑制剂
- 专利标题： SPIROPIPERIDINE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHERMER S DISEASE
- 专利标题（中）： 螺哌啶化合物作为阿尔茨海默氏病的治疗β-分泌酶抑制剂
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申请号： EP05812233.4申请日： 2005-10-12
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公开(公告)号： EP1804794A2公开(公告)日： 2007-07-11
- 发明人: BARROW, James, C. , COBURN, Craig, A. , EGBERTSON, Melissa, S. , MCGAUGHEY, Georgia, B. , MCWHERTER, Melody, A. , NEILSON, Lou, Anne , SELNICK, Harold, G. , STAUFFER, Shaun, R. , YANG, Zhi-Qiang , YANG, Wenjin , LU, Wanli , FAHR, Bruce , RITTLE, Kenneth, E.
- 申请人： Merck & Co., Inc. , Sunesis Pharmaceuticals, Inc.
- 申请人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 专利权人： Merck & Co., Inc.,Sunesis Pharmaceuticals, Inc.
- 当前专利权人： Merck & Co., Inc.,Sunesis Pharmaceuticals, Inc.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 代理机构： Buchan, Gavin MacNicol
- 优先权： US618420P 20041013
- 国际公布： WO2006044497 20060427
- 主分类号： A61K31/438
- IPC分类号： A61K31/438 ; C07D401/04
摘要：
The present invention is directed to spiropiperidine compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
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