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1.发明公开SPIROPIPERIDINE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHERMER S DISEASE 有权螺哌啶化合物作为阿尔茨海默氏病的治疗β-分泌酶抑制剂
公开(公告)号：EP1804794A2
公开(公告)日：2007-07-11
申请号：EP05812233.4
申请日：2005-10-12
发明人： BARROW, James, C. , COBURN, Craig, A. , EGBERTSON, Melissa, S. , MCGAUGHEY, Georgia, B. , MCWHERTER, Melody, A. , NEILSON, Lou, Anne , SELNICK, Harold, G. , STAUFFER, Shaun, R. , YANG, Zhi-Qiang , YANG, Wenjin , LU, Wanli , FAHR, Bruce , RITTLE, Kenneth, E.
IPC分类号： A61K31/438 , C07D401/04
CPC分类号： C07D471/10
摘要： The present invention is directed to spiropiperidine compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
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2.发明公开SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 审中-公开螺哌啶β-分泌酶抑制剂用于治疗阿尔茨海默氏病的治疗
公开(公告)号：EP2063889A2
公开(公告)日：2009-06-03
申请号：EP07811660.5
申请日：2007-09-04
发明人： EGBERTSON, Melissa, S. , STAUFFER, Shaun, R. , COBURN, Craig, A. , BARROW, James, C. , YANG, Wenjin , LU, Wanli , FAHR, Bruce , NEILSON, Lou Anne , WAI, Jenny M.
IPC分类号： A61K31/438 , C07D471/10 , C07D498/10
CPC分类号： C07D471/10 , C07D498/10
摘要： The present invention is directed to spiropiperidine compounds of formula (I) and tautomers thereof, which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
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3.发明公开SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 有权SPIROPIPERIDININHIBITORENβ-分泌阿尔茨海默氏病的治疗
公开(公告)号：EP1910364A2
公开(公告)日：2008-04-16
申请号：EP06787495.8
申请日：2006-07-14
发明人： COBURN, Craig, A. , EGBERTSON, Melissa, S. , GRAHAM, Samuel, L. , MCGAUGHEY, Georgia, B. , STAUFFER, Shaun, R. , RAJAPAKSE, Hemaka, A. , NANTERMET, Philippe, G. , STACHEL, Shawn, R. , YANG, Wenjin , LU, Wanli , FAHR, Bruce
IPC分类号： C07D471/10 , A61K31/438 , A61P25/28
CPC分类号： C07D471/10
摘要： The present invention is directed to spiropiperidine compounds of formula (I) and tautomers thereof, which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
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4.发明授权SPIROPIPERIDINE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHERMER S DISEASE 有权螺哌啶化合物作为阿尔茨海默氏病的治疗β-分泌酶抑制剂
公开(公告)号：EP1804794B1
公开(公告)日：2013-07-31
申请号：EP05812233.4
申请日：2005-10-12
发明人： BARROW, James, C. , COBURN, Craig, A. , EGBERTSON, Melissa, S. , MCGAUGHEY, Georgia, B. , MCWHERTER, Melody, A. , NEILSON, Lou, Anne , SELNICK, Harold, G. , STAUFFER, Shaun, R. , YANG, Zhi-Qiang , YANG, Wenjin , LU, Wanli , FAHR, Bruce , RITTLE, Kenneth, E.
IPC分类号： A61K31/438 , C07D401/04
CPC分类号： C07D471/10
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5.发明授权SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 有权SPIROPIPERIDININHIBITORENβ-分泌阿尔茨海默氏病的治疗
公开(公告)号：EP1910364B1
公开(公告)日：2012-03-21
申请号：EP06787495.8
申请日：2006-07-14
发明人： COBURN, Craig, A. , EGBERTSON, Melissa, S. , GRAHAM, Samuel, L. , MCGAUGHEY, Georgia, B. , STAUFFER, Shaun, R. , RAJAPAKSE, Hemaka, A. , NANTERMET, Philippe, G. , STACHEL, Shawn, R. , YANG, Wenjin , LU, Wanli , FAHR, Bruce
IPC分类号： C07D471/10 , A61K31/438 , A61P25/28
CPC分类号： C07D471/10
摘要： The present invention is directed to spiropiperidine compounds of formula (I) and tautomers thereof, which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
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公开(公告)号：EP0664792B1
公开(公告)日：2000-01-05
申请号：EP93923845.7
申请日：1993-10-12
申请人： Merck & Co., Inc.
IPC分类号： A61K31/445 , A61K31/34 , A61K31/38 , C07D409/06 , C07D401/06 , C07D401/12 , C07D405/06 , A61K31/395 , A61K31/415 , A61K31/42 , A61K31/405 , A61K31/335
CPC分类号： C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06
摘要： Fibrinogen receptor antagonists of formulae (I) and (II) are disclosed for use in inhibiting the binding of fibrinogen to blood platelets and for inhibiting the aggregation of blood platelets.
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公开(公告)号：EP0673247A1
公开(公告)日：1995-09-27
申请号：EP94904069.0
申请日：1993-11-29
申请人： MERCK & CO. INC.
发明人： EGBERTSON, Melissa, S. , TURCHI, Laura, M. , HARTMAN, George, D. , HALCZENKO, Wasyl , WHITMAN, David, B. , PERKINS, James, J. , KRAUSE, Amy, E. 570 W. Dekalb Pike , IHLE, Nathan , CLAREMON, David, Alan , HOFFMAN, William , DUGGAN, Mark, E.
IPC分类号： C07D295 , A61K31 , A61P7 , A61P43 , C07C255 , C07C271 , C07C309 , C07C311 , C07D205 , C07D207 , C07D211 , C07D213 , C07D233 , C07D401 , C07D409 , C07D521
CPC分类号： C07D213/30 , C07C311/19 , C07D205/04 , C07D211/22 , C07D211/26 , C07D211/34 , C07D211/46 , C07D211/70 , C07D213/71 , C07D231/12 , C07D233/56 , C07D233/64 , C07D249/08 , C07D295/084 , C07D295/088 , C07D295/096 , C07D295/155 , C07D401/12 , C07D409/12
摘要： Novel fibrinogen receptor antagonists of the formula: X-Y-Z-Aryl-A-B are provided in which the claimed compounds exhibit fibrinogen receptor antagonist activity, inhibit platelet aggregation and are therefore useful in modulating thrombus formation.
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公开(公告)号：EP0912513A1
公开(公告)日：1999-05-06
申请号：EP97931401.0
申请日：1997-06-25
申请人： MERCK & CO., INC.
发明人： YOUNG, Steven, D. , HARTMAN, George, D. , LIBBY, Laura, A. , EGBERTSON, Melissa, S. , SLAUGHTER, Donald, E.
CPC分类号： C07D213/73 , C07D209/46 , C07D211/34 , C07D211/76 , C07D295/155 , C07D401/06 , C07D471/04 , C07D487/04
摘要： Fibrinogen receptor antagonist alcohol prodrugs having the structure, for example, of X-W-Y-Z-A-B more particularly of formula (A).
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公开(公告)号：EP0912182A1
公开(公告)日：1999-05-06
申请号：EP97931396.0
申请日：1997-06-25
申请人： MERCK & CO., INC.
发明人： EGBERTSON, Melissa, S. , HARTMAN, George, D. , LUMMA, William, C. , WAI, John, S. , YOUNG, Steven, D.
CPC分类号： C07D295/205 , A61K45/06 , C07D213/71 , C07D295/155 , C07D401/04 , C07D471/04
摘要： Fibrinogen receptor antagonist alcohol prodrugs having the structure, for example, of formula (I) more particularly, formulae (II) and (III).
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公开(公告)号：EP0912175A1
公开(公告)日：1999-05-06
申请号：EP97932307.0
申请日：1997-06-25
申请人： MERCK & CO., INC.
发明人： DUGGAN, Mark, E. , EGBERTSON, Melissa, S. , HARTMAN, George, D. , YOUNG, Steven, D. , IHLE, Nathan, C.
IPC分类号： C07D295 , A61K31 , A61P7 , C07D207 , C07D209 , C07D211 , C07D213 , C07D333 , C07D401 , C07D471 , C07D487 , C07D491
CPC分类号： C07D213/70 , C07D207/14 , C07D209/08 , C07D209/46 , C07D211/26 , C07D211/62 , C07D213/53 , C07D213/73 , C07D213/82 , C07D295/155 , C07D333/70 , C07D401/04 , C07D471/04 , C07D487/04 , C07D491/04
摘要： Fibrinogen receptor antagonists having the structure X-Y-Z-A-B and pharmaceutically acceptable salts, wherein X is a 5, 6 or 7 membered aromatic or nonaromatic ring, and Y is a 5 or 6 membered aromatic ring, e.g., formula (I).
摘要翻译： 具有结构X-Y-Z-A-B及其药学上可接受的盐的纤维蛋白原受体拮抗剂，其中X是5,6或7元芳族或非芳族环，并且Y是5或6元芳族环，例如式（I）。
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