发明公开
EP1809301A2 PREPARATION OF 2'FLUORO-2'-ALKYL-SUBSTITUTED OR OTHER OPTIONALLY SUBSTITUTED RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES
审中-公开
制造'氟代-2'-烷基取代或以其他方式可选取代核糖基嘧啶和嘌呤及其衍生物
- 专利标题： PREPARATION OF 2'FLUORO-2'-ALKYL-SUBSTITUTED OR OTHER OPTIONALLY SUBSTITUTED RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES
- 专利标题（中）： 制造'氟代-2'-烷基取代或以其他方式可选取代核糖基嘧啶和嘌呤及其衍生物
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申请号： EP05808357.7申请日： 2005-09-13
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公开(公告)号： EP1809301A2公开(公告)日： 2007-07-25
- 发明人: CHUN, Byoung-Kwon , WANG, Peiyuan , DU, Jinfa , RACHAKONDA, Suguna
- 申请人： Pharmasset, Inc.
- 申请人地址： 303A College Road East Princeton, NJ 08540 US
- 专利权人： Pharmasset, Inc.
- 当前专利权人： Pharmasset, Inc.
- 当前专利权人地址： 303A College Road East Princeton, NJ 08540 US
- 代理机构： Portal, Frédéric
- 优先权： US609783P 20040914; US610035P 20040915; US666230P 20050329
- 国际公布： WO2006031725 20060323
- 主分类号： A61K31/7072
- IPC分类号： A61K31/7072
摘要：
The present invention provides (i) processes for preparing a 2'-deoxy-2'fluoro-2'-methyl-D-ribonolactone derivatives, (ii) conversion of intermediate lactones to nucleosides with potent anti-HCV activity, and their analogues, and (iii) methods to prepare the anti-HCV nucleosides containing the 2'-deoxy-2'-fluoro-2'-C-methyl-ss-D-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside.
公开/授权文献
- EP1809301B1 2-FLUORO-2-ALKYL-SUBSTITUTED D-RIBONOLACTONE INTERMEDIATES 公开/授权日：2019-11-06
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