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公开(公告)号：EP1534255A2
公开(公告)日：2005-06-01
申请号：EP03789692.5
申请日：2003-08-06
申请人： Pharmasset, Inc.
发明人： WATANABE, Kyoichi, A. , DU, Jinfa
IPC分类号： A61K31/00
CPC分类号： C07D317/32 , C07D405/04 , C07D473/04 , C07D473/16 , C07D473/20 , C07D493/08
摘要： Disclosed are novel processes for preparing 1,3-dioxolane nucleosides of feneral formula I and II : wherein B is a purine or pyrimidine base or an analog or derivative thereof. The invention also provides intermediates for use in the preparation of these compounds.
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公开(公告)号：EP2313422A2
公开(公告)日：2011-04-27
申请号：EP09763386.1
申请日：2009-06-08
申请人： Pharmasset, Inc.
发明人： DU, Jinfa , NAGARATHNAM, Dhanapalan , PAMULAPATI, Ganapati, Reddy , ROSS, Bruce, S. , SOFIA, Michael, Joseph
IPC分类号： C07H19/10 , C07H19/20 , C07D473/18
CPC分类号： C07D473/18 , C07H19/10 , C07H19/20
摘要： Cyclic phosphate of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomers, salts (acid or basic addition salts), hydrates, solvates, or crystalline forms thereof, represented by the following structure: Formula (I)
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3.发明公开2',4'-SUBSTITUTED NUCLEOSIDES AS ANTIVIRAL AGENTS 有权2'，4'-SUBSTITUIERTE NUKLEOSIDE ALS ANTIVIRALE MITTEL
公开(公告)号：EP2227482A1
公开(公告)日：2010-09-15
申请号：EP08852934.2
申请日：2008-11-17
申请人： Pharmasset, Inc.
发明人： SOFIA, Michael, J. , DU, Jinfa
IPC分类号： C07H19/06 , C07H19/16 , A61K31/7068 , A61K31/7076 , A61P31/12
CPC分类号： C07H19/06 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , C07H19/073 , C07H19/14 , C07H19/16 , C07H19/173
摘要： Embodiments of the invention are to compounds of formulae (A), (A'), methods, and compositions for use in the treatment of viral infections. More specifically embodiments of the invention are 2 ', 4 ' -substituted nucleoside compounds useful for the treatment of viral infections, such as HIV, HCV, and HBV infections.
摘要翻译： 本发明的实施方案是用于治疗病毒感染的式（A），（A'），方法和组合物的化合物。 更具体地，本发明的实施方案是用于治疗病毒感染的2'，4'-取代的核苷化合物，例如HIV，HCV和HBV感染。
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公开(公告)号：EP2376088A2
公开(公告)日：2011-10-19
申请号：EP09795670.0
申请日：2009-12-23
申请人： Pharmasset, Inc.
IPC分类号： A61K31/7076
CPC分类号： C07H19/20
摘要： A nucleoside compound having activity against hepatitis C virus is disclosed.
摘要翻译： 公开了具有抗丙型肝炎病毒活性的核苷化合物。
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5.发明公开PREPARATION OF ALKYL-SUBSTITUTED 2-DEOXY-2-FLUORO-D-RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES 有权烷基取代的2-脱氧-2- FLUOR-D RIBOFURANOSYLPYRIMIDINEN及其衍生物-PURINEN的生产
公开(公告)号：EP1773856A2
公开(公告)日：2007-04-18
申请号：EP05775359.2
申请日：2005-07-21
申请人： Pharmasset, Inc.
发明人： WANG, Peiyuan , CHUN, Byoung-Kwon , SHI, Junxing , DU, Jinfa , STEC, Wojciech, Kolonia Wola Zaradzynski
CPC分类号： C07H19/173 , C07H19/073
摘要： The present invention provides (i) a process for preparing a 2-deoxy-2-fluoro-2-methyl-D-ribonolactone derivative, (ii) conversion of the lactone to nucleosides with potent anti-HCV activity, and their analogues, and (iii) a method to prepare the anti-HCV nucleosides containing the 2-deoxy-2-fluoro-2-C-methyl-β-D-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside.
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公开(公告)号：EP2376515A1
公开(公告)日：2011-10-19
申请号：EP09793688.4
申请日：2009-12-23
申请人： Pharmasset, Inc.
发明人： CHUN, Byoung-kwon , DU, Jinfa , RACHAKONDA, Suguna , ROSS, Bruce, S. , SOFIA, Michael, Joseph , PAMULAPATI, Ganapati, Reddy , CHANG, Wonsuk , ZHANG, Hai-ren , NAGARATHNAM, Dhanapalan
IPC分类号： C07H19/167 , C07H19/20 , C07H19/213 , A61K31/7076 , A61P31/14
CPC分类号： C07H19/20 , C07H1/00 , C07H5/02 , C07H15/04 , C07H19/167 , C07H19/213 , Y02P20/55
摘要： A process for preparing phosphoramidate prodrugs or cyclic phosphate prodrugs of nucleoside derivatives, which is a compound, its stereoisomers, salts (acid or basic addition salts), hydrates, solvates, or crystalline forms thereof.
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公开(公告)号：EP1534255B1
公开(公告)日：2011-01-19
申请号：EP03789692.5
申请日：2003-08-06
申请人： Pharmasset, Inc.
发明人： WATANABE, Kyoichi, A. , DU, Jinfa
IPC分类号： C07D493/08 , C07D405/04 , C07D473/04 , C07D473/20 , C07D473/16 , C07D317/32
CPC分类号： C07D317/32 , C07D405/04 , C07D473/04 , C07D473/16 , C07D473/20 , C07D493/08
摘要： Disclosed are novel processes for preparing 1,3-dioxolane nucleosides of feneral formula I and II : wherein B is a purine or pyrimidine base or an analog or derivative thereof. The invention also provides intermediates for use in the preparation of these compounds.
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公开(公告)号：EP1937825A2
公开(公告)日：2008-07-02
申请号：EP06825120.6
申请日：2006-09-26
申请人： Pharmasset, Inc.
发明人： DU, Jinfa , FURMAN, Phillip , SOFIA, Michael
摘要： Compounds, methods and compositions for treating a host infected with human immunodeficiency virus and hepatitis B virus comprising administering an effective amount of a described 4'-C-substituted /3-D- and /3-L-nucleoside or a pharmaceutically acceptable salt or prodrug thereof, are provided.
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9.发明授权PREPARATION OF ALKYL-SUBSTITUTED 2-DEOXY-2-FLUORO-D-RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES 有权烷基取代的2-脱氧-2- FLUOR-D RIBOFURANOSYLPYRIMIDINEN及其衍生物-PURINEN的生产
公开(公告)号：EP1773856B1
公开(公告)日：2012-02-01
申请号：EP05775359.2
申请日：2005-07-21
申请人： Pharmasset, Inc.
发明人： WANG, Peiyuan , CHUN, Byoung-Kwon , SHI, Junxing , DU, Jinfa , STEC, Wojciech, Kolonia Wola Zaradzynski , CLARK, Jeremy
IPC分类号： C07B37/00
CPC分类号： C07H19/173 , C07H19/073
摘要： The present invention provides (i) a process for preparing a 2-deoxy-2-fluoro-2-methyl-D-ribonolactone derivative, (ii) conversion of the lactone to nucleosides with potent anti-HCV activity, and their analogues, and (iii) a method to prepare the anti-HCV nucleosides containing the 2-deoxy-2-fluoro-2-C-methyl-β-D-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside.
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公开(公告)号：EP2203462A2
公开(公告)日：2010-07-07
申请号：EP08732818.3
申请日：2008-03-26
申请人： Pharmasset, Inc.
IPC分类号： C07H19/10 , C07H19/20 , C07H19/04 , C07H19/06 , A61K31/7064 , A61K31/7076 , A61K31/706 , A61P31/14
CPC分类号： A61K31/7072 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7076 , A61K45/06 , C07D417/14 , C07H17/02 , C07H19/04 , C07H19/06 , C07H19/073 , C07H19/10 , C07H19/20 , Y02A50/463
摘要： Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound represented by the following structure: Also disclosed are methods of treatment, uses, and processes for preparing the compounds represented by formula I.
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