发明公开
- 专利标题： HYDRAZIDE DERIVATIVES
- 专利标题（中）： HYDRAZIDDERIVATE
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申请号： EP05793650.2申请日： 2005-10-13
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公开(公告)号： EP1810965A1公开(公告)日： 2007-07-25
- 发明人: CLARK, Richard , HIROTA, Shinsuke , AZUMA, Hiroshi , KIRA, Kazunobu , WATANABE, Nobuhisa , NAGAKURA, Tadashi , HORIZOE, Tatsuo
- 申请人： Eisai R&D Management Co., Ltd.
- 申请人地址： 6-10, Koishikawa 4-chome, Bunkyo-ku Tokyo 112-8088 JP
- 专利权人： Eisai R&D Management Co., Ltd.
- 当前专利权人： Eisai R&D Management Co., Ltd.
- 当前专利权人地址： 6-10, Koishikawa 4-chome, Bunkyo-ku Tokyo 112-8088 JP
- 代理机构： HOFFMANN EITLE
- 优先权： JP2004298379 20041013
- 国际公布： WO2006041119 20060420
- 主分类号： C07C257/18
- IPC分类号： C07C257/18 ; A61K31/16 ; A61K31/196 ; A61K31/275 ; A61K31/341 ; A61K31/381 ; A61K31/4035 ; A61K31/404 ; A61K31/417 ; A61K31/4178 ; A61K31/4192 ; A61K31/44 ; A61K31/4402 ; A61K31/4406 ; A61K31/4409 ; A61K31/455 ; A61K31/47 ; A61K31/4965 ; A61K31/50 ; A61K31/505
摘要：
A compound represented by the following general formula (1) or a salt thereof or a hydrate of the foregoing is safe while exhibiting suitable physicochemical stability, and is useful as therapeutic or prophylactic agents for diseases associated with thrombus formation.
wherein R 1a , R 1b , R 1c and R 1d each independently represent hydrogen, etc., R 2 represents optionally substituted phenyl, etc., R 3 represents optionally substituted C6-10 aryl, etc., Z 1 , Z 2 and Z 3 each independently represent hydrogen, etc., Z 4 represents hydrogen, etc. and X represents a single bond or -CO-, etc.
wherein R 1a , R 1b , R 1c and R 1d each independently represent hydrogen, etc., R 2 represents optionally substituted phenyl, etc., R 3 represents optionally substituted C6-10 aryl, etc., Z 1 , Z 2 and Z 3 each independently represent hydrogen, etc., Z 4 represents hydrogen, etc. and X represents a single bond or -CO-, etc.
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