发明公开
- 专利标题： MODIFIED NUCLEOSIDES FOR RNA INTERFERENCE
- 专利标题（中）： 用于RNA干扰的修饰核苷酸
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申请号： EP05804121.1申请日： 2005-11-08
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公开(公告)号： EP1812569A2公开(公告)日： 2007-08-01
- 发明人: HERDEWIJN, Piet , VAN AERSCHOT, Arthur , WANG, Jing , JULIANO, Rudy
- 申请人： K.U. Leuven Research and Development , THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
- 申请人地址： Groot Begijnhof 58-59 3000 Leuven BE
- 专利权人： K.U. Leuven Research and Development,THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
- 当前专利权人： K.U. Leuven Research and Development,THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
- 当前专利权人地址： Groot Begijnhof 58-59 3000 Leuven BE
- 代理机构： pronovem
- 优先权： GB0424600 20041108; GB0427106 20041210; GB0428476 20041230
- 国际公布： WO2006047842 20060511
- 主分类号： C12N15/11
- IPC分类号： C12N15/11
摘要：
The present invention relates to the use of modified nucleotides and single or double stranded oligonucleotides comprising at least one of said modified nucleotides for performing RNA interference. The modified nucleotides are selected from 6-membered ring containing nucleotides such as hexitol, altritol, O-subsituted or O-alkylated altritol, cyclohexenyl, ribo-cyclohexenyl and O-subsituted or O-alkylated ribo-cyclohexenyl nucleotides. The present invention also relates to novel modified nucleosides or nucleotides and to the use of said novel modified nucleosides and nucleotides in single or double stranded oligonucleotides for RNA interference, antisense therapy or other applications.
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