公开(公告)号：EP1620707B1

公开(公告)日：2017-12-27

申请号：EP04731555.1

申请日：2004-05-07

申请人： K.U. Leuven Research and Development

发明人： DE BAERDEMAEKER, Josse ,  DE KETELAERE, Bart ,  KAMERS, Bram

IPC分类号： B29L31/00 ,  B29C65/08 ,  B29C65/82 ,  B29C65/04 ,  B29K101/12 ,  G01M3/24

CPC分类号： G01M3/24 ,  B29C65/04 ,  B29C65/08 ,  B29C65/8253 ,  B29C65/8292 ,  B29K2101/12 ,  B29L2031/712 ,  B29L2031/7164

公开(公告)号：EP2139463B1

公开(公告)日：2014-08-20

申请号：EP08716611.2

申请日：2008-03-18

申请人： Technische Universität Carolo-Wilhelmina zu Braunschweig ,  K.U. Leuven Research and Development

发明人： MAZIK, Monika ,  BALZARINI, Jan

IPC分类号： A61K47/48 ,  A61K31/15 ,  A61K31/167 ,  A61K31/44 ,  A61K31/4375 ,  A61P31/00 ,  A61P31/04 ,  A61P31/12 ,  A61P31/14 ,  A61P31/18 ,  A61P31/20 ,  A61P31/22

CPC分类号： A61K31/15 ,  A61K31/167 ,  A61K31/4375 ,  A61K31/44 ,  A61K47/55

公开(公告)号：EP1989312B1

公开(公告)日：2011-10-19

申请号：EP07703096.3

申请日：2007-01-29

申请人： VIB, vzw ,  K.U. Leuven Research and Development

发明人： LEYMAN, Barbara ,  RAMON, Matthew ,  ROLLAND, Filip ,  THEVELEIN, Johan ,  VAN DIJCK, Patrick ,  VANDESTEENE, Lies

IPC分类号： C12N15/82 ,  C12N9/10

CPC分类号： C12N15/8261 ,  C12N9/1051 ,  Y02A40/146

摘要： The present invention relates to the use of trehalose-6-phosphate synthase to modulate plant growth. More specifically, it relates to the use of a class II trehalose-6-phosphate synthase, comprising both a synthase and a phosphatase-like part to modulate plant growth. Preferably, the activity of trehalose-6-phosphate synthase is down-regulated to obtain an increased plant biomass yield.

公开(公告)号：EP2015747A2

公开(公告)日：2009-01-21

申请号：EP07719209.4

申请日：2007-05-10

申请人： K.U. Leuven Research and Development

发明人： PANNECOUQUE, Chrsitophe ,  ROBBERECHT, Wim ,  STEVENS, Miguel

IPC分类号： A61K31/4178 ,  A61K31/4164 ,  A61P5/48 ,  A61P9/00 ,  A61P25/28 ,  A61P25/16 ,  A61P33/02

CPC分类号： A61K31/4178 ,  A61K31/4164

摘要： The present invention relates to the use of N-aminoimidazole or N- aminoimidazole-thione derivatives as cytoprotective compounds in vitro and in vivo and for the treatment or prevention of cell death mediated disorders and/or GSK-3 mediated disorders or processes.

公开(公告)号：EP1758997B1

公开(公告)日：2008-12-10

申请号：EP05749119.3

申请日：2005-06-07

申请人： VIB vzw ,  K.U. Leuven Research and Development

发明人： COOLS, Jan ,  HAGEMEIJER, Anne ,  MARYNEN, Peter

IPC分类号： C12N15/00 ,  C12N5/00 ,  C12N1/20 ,  C07H21/04 ,  C12Q1/68

CPC分类号： C07K14/82 ,  C12N9/1205

摘要： The present invention relates to an episomal structure expressing a functional oncogene, whereby said oncogene is a fusion gene of two chromosomal gene fragments. More specifically, the invention relates to a NUP214-ABL1 fusion product, important in the development of T-cell acute lymphoblastic leukemia, to methods to detect the fusion and to methods to prevent the oncogenic activity of said fusion product.

公开(公告)号：EP1901355A1

公开(公告)日：2008-03-19

申请号：EP07075809.9

申请日：2007-09-17

申请人： Interuniversitair Microelektronica Centrum ,  K.U. Leuven Research and Development

发明人： Verhulst, Anne S. ,  Vandenberghe, William G.

IPC分类号： H01L29/423 ,  H01L29/772 ,  H01L29/78 ,  H01L29/06

CPC分类号： H01L29/0665 ,  B82Y10/00 ,  H01L29/0673 ,  H01L29/0676 ,  H01L29/068 ,  H01L29/165 ,  H01L29/7391

摘要： Tunnel field-effect transistors (TFETs) are regarded as successors of metal-oxide semiconductor field-effect transistors (MOSFETs), but silicon-based TFETs typically suffer from low on-currents, a drawback related to the large resistance of the tunnel barrier. To achieve higher on-currents an elongate monocrystalline nanostructure-based TFET with a germanium (Ge) tunnel barrier in an otherwise silicon (Si) channel is used. An elongate monocrystalline nanostructure is introduced such that the lattice mismatch between silicon and germanium does not result in a highly defective interface. A dynamic power reduction as well as a static power reduction can result, compared to conventional MOSFET configurations. Multiple layers of logic can therefore be envisioned with these elongate monocrystalline nanostructure Si/Ge TFETs resulting in ultra-high on-chip transistor densities.

摘要翻译： 隧道场效应晶体管（TFET）被认为是金属氧化物半导体场效应晶体管（MOSFET）的后继者，但是硅基TFET通常具有低导通电流，这是与隧道势垒的大电阻相关的缺点。 为了实现更高的导通电流，使用在另外的硅（Si）通道中具有锗（Ge）隧道势垒的细长单晶纳米结构的TFET。 引入细长单晶纳米结构，使得硅和锗之间的晶格失配不会导致高度缺陷的界面。 与常规MOSFET配置相比，可以实现动态功耗降低和静态功耗降低。 因此，可以用这些细长单晶纳米结构Si / Ge TFET来设想多层逻辑，从而产生超高的片上晶体管密度。

公开(公告)号：EP1899089A2

公开(公告)日：2008-03-19

申请号：EP06741294.0

申请日：2006-04-21

申请人： K.U. Leuven Research and Development

发明人： CALLEBAUT, Bart ,  DUFLOU, Joost ,  VERBERT, Johan

IPC分类号： B21D22/18

CPC分类号： B21D31/005

摘要： The present invention relates, in general, to sheet material forming technology and the forming of structures there from. The invention relates to incremental forming of sheet material (1) with localised heating (5) and more particularly to a system and method for incrementally forming a sheet blank (1) that is at the same time heated by a dynamically moving heating source (5). This dynamic and localised heating locally changes the mechanical properties of the sheet material (1), thus facilitating the forming process.

摘要翻译： 本发明一般涉及片材成型技术及其结构的形成。 本发明涉及具有局部加热（5）的片状材料（1）的增量成型，更具体地涉及用于逐渐形成板坯（1）的系统和方法，该系统和方法同时由动态移动的加热源（5 ）。 这种动态和局部加热局部地改变了片材（1）的机械性能，从而有助于成型过程。

公开(公告)号：EP1812088A2

公开(公告)日：2007-08-01

申请号：EP05808071.4

申请日：2005-11-08

申请人： K.U. Leuven Research and Development ,  AlphaGen N.V.

发明人： FLAMENG, Willem ,  DE VISSCHER, Geofrey

IPC分类号： A61L27/38 ,  A61L27/50

CPC分类号： A61L27/3641 ,  A61L27/3625 ,  A61L27/3645 ,  A61L27/3683 ,  A61L27/38 ,  A61L27/3804 ,  A61L27/3843 ,  A61L27/50

摘要： The present invention relates to matrices comprising homing factors for in vivo recellularisation of implantable medical devices such as cardiac valves and vascular grafts.

公开(公告)号：EP1482975B1

公开(公告)日：2006-12-13

申请号：EP03702560.8

申请日：2003-01-29

申请人： Vlaams Interuniversitair Instituut voor Biotechnologie vzw. ,  Thromb-X ,  K.U. Leuven Research and Development

发明人： KONINCKX, Philippe ,  CARMELIET, Peter ,  COLLEN, Désiré ,  MOLINAS SANABRIA, Carlos, Roger

IPC分类号： A61K45/00 ,  A61K41/00 ,  A61K39/395

CPC分类号： C12N15/113 ,  A61K31/00 ,  A61K38/1709 ,  A61K2039/505 ,  C07K14/4702 ,  C07K16/22 ,  C12N15/1136 ,  C12N2310/12 ,  C12N2310/13

摘要： The present invention is concerned with compositions for use in the medical art. More particularly the invention relates to uses of inhibitors against hypoxia-induced genes for the manufacture of a medicament to prevent and/or to suppress post-operative/post-wounding adhesions formation. Post-operative adhesions are an unwanted result from surgery and are a major source of postoperative morbidity and mortality. The invention applies to human and veterinary applications. To date, no single therapeutic approach has proven universally effective in preventing formation of post-operative adhesions formations.

公开(公告)号：EP1699546A2

公开(公告)日：2006-09-13

申请号：EP04802153.9

申请日：2004-12-16

申请人： K.U. Leuven Research and Development

发明人： VANKELECOM, Ivo ,  GEVERS, Lieven ,  JACOBS, Pierre

IPC分类号： B01D69/14 ,  B01D61/02 ,  B01D61/14

CPC分类号： B01D69/141 ,  B01D61/025 ,  B01D61/027 ,  B01D61/145 ,  B01D61/147 ,  B01D71/24 ,  B01D71/70

摘要： Membranes consisting of an elastomeric matrix with dispersed fillers are used in the pressure driven separation of liquid feeds. The fillers are selected in such a way that the interactions between the filler and the elastomer keep the membrane swelling limited, resulting in higher rejections.