发明公开
EP1812581A2 PROCESS FOR THE PREPARATION OF AN OPTICALLY ACITIVE N-CARBAMATE PROTECTED BETA-LACTAM BY OPTICAL RESOLUTION EMPLOYING A CANDIDA ANTARCTICA LIPASE
有权
用于生产光学活性的N-氨基甲酸酯PROTECTEDβ-内酰胺类进行旋光拆分USING A南极假丝酵母脂肪酶
- 专利标题： PROCESS FOR THE PREPARATION OF AN OPTICALLY ACITIVE N-CARBAMATE PROTECTED BETA-LACTAM BY OPTICAL RESOLUTION EMPLOYING A CANDIDA ANTARCTICA LIPASE
- 专利标题（中）： 用于生产光学活性的N-氨基甲酸酯PROTECTEDβ-内酰胺类进行旋光拆分USING A南极假丝酵母脂肪酶
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申请号： EP05826088.6申请日： 2005-11-15
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公开(公告)号： EP1812581A2公开(公告)日： 2007-08-01
- 发明人: ARGADE, Ankush
- 申请人： Rigel Pharmaceuticals, Inc.
- 申请人地址： 1180 Veterans Boulevard South San Francisco, CA 94080 US
- 专利权人： Rigel Pharmaceuticals, Inc.
- 当前专利权人： Rigel Pharmaceuticals, Inc.
- 当前专利权人地址： 1180 Veterans Boulevard South San Francisco, CA 94080 US
- 代理机构： Mallalieu, Catherine Louise
- 优先权： US628401P 20041115
- 国际公布： WO2006055528 20060526
- 主分类号： C12P17/10
- IPC分类号： C12P17/10 ; C12P41/00
摘要：
The present disclosure provides enzymatic methods for generating stereoisomerically pure products by resolving a racemic mixture of N-protected β-lactams with a lipase from Candida antarctica with high stereospecificity. The presence of a carbamate protecting group, such as the tert-butoxycarbonyl group protecting group, on the (3-lactam enhances enzyme catalysis and stereoselectivity.
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