发明公开
EP1814553A2 GTPASE INHIBITORS AND USE THEREOF FOR CONTROLLING PLATELET HYPERACTIVITY
审中-公开
GTP酶抑制剂及它们在调节血小板多动症
- 专利标题： GTPASE INHIBITORS AND USE THEREOF FOR CONTROLLING PLATELET HYPERACTIVITY
- 专利标题（中）： GTP酶抑制剂及它们在调节血小板多动症
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申请号： EP05851860.6申请日： 2005-11-18
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公开(公告)号： EP1814553A2公开(公告)日： 2007-08-08
- 发明人: ZHENG, Yi , AKBAR, Huzoor , WILLIAMS, David A. , MAZUR, Wieslaw Adam
- 申请人： Children's Hospital Medical Center , Girindus America, Inc.
- 申请人地址： 3333 Burnet Avenue, Mlc 7032 Cincinnati, OH 45229-3039 US
- 专利权人： Children's Hospital Medical Center,Girindus America, Inc.
- 当前专利权人： Children's Hospital Medical Center,Girindus America, Inc.
- 当前专利权人地址： 3333 Burnet Avenue, Mlc 7032 Cincinnati, OH 45229-3039 US
- 代理机构： Mallalieu, Catherine Louise
- 优先权： US629380P 20041119
- 国际公布： WO2006055833 20060526
- 主分类号： A61K31/505
- IPC分类号： A61K31/505
摘要：
The preferred embodiments generally relate to methods and compositions that affect the GTP-binding activity of members of the Rho family GTPases, preferably Rac (Rac1, Rac2 and/or Rac3), such compositions include compounds that modulate the GTP/GDP exchange activity, along with uses for the compounds including screening for compounds which recognize Rac GTPase, and methods of treating pathological conditions associated or related to a Rho family GTPase, including Rac. The preferred embodiments also relate to methods of using such compounds, or derivatives thereof, e.g., in therapeutics, diagnostics, and as research tools.
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