发明公开
EP1817312A1 MACROCYCLIC AMINOPYRIDYL BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
有权
阿尔茨海默氏病的治疗MACRO CYCLICAL AMINIOPYRIDYL-β分泌酶抑制剂
- 专利标题： MACROCYCLIC AMINOPYRIDYL BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
- 专利标题（中）： 阿尔茨海默氏病的治疗MACRO CYCLICAL AMINIOPYRIDYL-β分泌酶抑制剂
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申请号： EP05849049.1申请日： 2005-11-18
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公开(公告)号： EP1817312A1公开(公告)日： 2007-08-15
- 发明人: RAJAPAKSE, Hemaka, A. , NANTERMET, Philippe, G. , SELNICK, Harold, G. , MOORE, Keith, P.
- 申请人： Merck & Co., Inc.
- 申请人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 US
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 US
- 代理机构： Buchan, Gavin MacNicol
- 优先权： US630319P 20041123
- 国际公布： WO2006057983 20060601
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; C07D421/04 ; C07D413/04 ; C07D401/04 ; A61K31/4353
摘要：
The present invention is directed to macrocyclic aminopyridyl compounds represented by general formula (I), which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
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