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1.发明公开MACROCYCLIC AMINOPYRIDYL BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 有权阿尔茨海默氏病的治疗MACRO CYCLICAL AMINIOPYRIDYL-β分泌酶抑制剂
公开(公告)号：EP1817312A1
公开(公告)日：2007-08-15
申请号：EP05849049.1
申请日：2005-11-18
申请人： Merck & Co., Inc.
IPC分类号： C07D471/04 , C07D421/04 , C07D413/04 , C07D401/04 , A61K31/4353
CPC分类号： C07D491/08
摘要： The present invention is directed to macrocyclic aminopyridyl compounds represented by general formula (I), which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
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2.发明公开2,3,4,6-SUBSTITUTED PYRIDYL DERIVATIVE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 有权2,3,4,6-取代的吡啶基衍生物化合物AS BETA-SEKTRETASE抑制剂用于治疗阿尔茨海默氏病的治疗
公开(公告)号：EP1817311A2
公开(公告)日：2007-08-15
申请号：EP05851916.6
申请日：2005-11-18
申请人： Merck & Co., Inc.
发明人： NANTERMET, Philippe, G. , STANTON, Matthew, G. , RAJAPAKSE, Hemaka, A. , SELNICK, Harold, G. , BARROW, James, C. , STAUFFER, Shaun, R. , VACCA, Joseph, P. , MOORE, Keith, P. , STACHEL, Shawn, J.
IPC分类号： C07D413/04
CPC分类号： C07D413/04 , C07D413/14
摘要： The present invention is directed to 2,3,4,6-substituted pyridyl derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
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3.发明公开
公开(公告)号：EP1841426A1
公开(公告)日：2007-10-10
申请号：EP06718444.0
申请日：2006-01-13
申请人： Merck & Co., Inc.
IPC分类号： A61K31/4245 , C07D271/06
CPC分类号： C07D413/04 , C07D271/10 , C07D271/107 , C07D405/04 , C07D413/06 , C07D413/08 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/06 , C07D451/02 , C07D453/02 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention is directed to tertiary carbinamine compounds having substituted heterocycles, which are inhibitors of the beta-secretase enzyme, and are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
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4.发明公开1,3,5-SUBSTITUTED PHENYL DERIVATIVE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 有权用于治疗阿尔茨海默病SUITABLE 1,3,5-取代PHENYLDERIVATVERBINDUNGEN的治疗ALSβ-分泌酶抑制剂
公开(公告)号：EP1740559A1
公开(公告)日：2007-01-10
申请号：EP05738682.3
申请日：2005-04-15
申请人： Merck & Co., Inc.
发明人： BARROW, James, C. , MCGAUGHEY, Georgia, B. , NANTERMET, Philippe, G. , RAJAPAKSE, Hemaka, A. , SELNICK, Harold, G. , STAUFFER, Shaun, R. , COBURN, Craig, A.
IPC分类号： C07D271/10
CPC分类号： C07D271/10 , C07D249/06 , C07D249/08 , C07D263/32 , C07D263/62 , C07D271/06 , C07D285/12 , C07D307/14 , C07D307/42 , C07D307/44 , C07D307/52 , C07D307/54 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14
摘要： The present invention is directed to 1,3,5-phenyl substituted derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
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5.发明公开BENZYLETHER AND BENZYLAMINO BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER S DISEASE 有权苄基和苄ASβ-分泌阿尔茨海默氏病的治疗抑制剂
公开(公告)号：EP1689713A1
公开(公告)日：2006-08-16
申请号：EP04811618.0
申请日：2004-11-19
申请人： Merck & Co., Inc.
发明人： NANTERMET, Philippe, G. , RAJAPAKSE, Hemaka, A. , SELNICK, Harold, G. , STAUFFER, Shaun, R. , YOUNG, Mary Beth
IPC分类号： C07D213/02 , A61K31/44
CPC分类号： C07C255/46 , C07C311/08 , C07C2601/02 , C07C2601/08 , C07D207/06 , C07D213/76 , C07D295/192 , C07D401/06
摘要： The present invention is directed to benzylether and benzylamino derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
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6.发明公开MACROCYCLIC TERTIARY AMINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 有权万家乐CYCLICAL叔胺β-分泌酶抑制剂用于治疗阿尔茨海默氏病的治疗
公开(公告)号：EP1814537A2
公开(公告)日：2007-08-08
申请号：EP05825640.5
申请日：2005-11-14
申请人： Merck & Co., Inc.
发明人： NANTERMET, Philippe, G. , RAJAPAKSE, Hemaka, A. , SELNICK, Harold, G. , LINDSLEY, Stacey , MOORE, Keith, P. , STACHEL, Shawn, J.
IPC分类号： A61K31/33
CPC分类号： C07D273/01 , C07D267/00 , C07D313/00 , C07D321/00 , C07D323/00 , C07D413/04 , C07D498/08
摘要： The present invention is directed to macrocyclic tertiary amine compounds represented by general formula (I), which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
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7.发明公开SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 有权SPIROPIPERIDININHIBITORENβ-分泌阿尔茨海默氏病的治疗
公开(公告)号：EP1910364A2
公开(公告)日：2008-04-16
申请号：EP06787495.8
申请日：2006-07-14
发明人： COBURN, Craig, A. , EGBERTSON, Melissa, S. , GRAHAM, Samuel, L. , MCGAUGHEY, Georgia, B. , STAUFFER, Shaun, R. , RAJAPAKSE, Hemaka, A. , NANTERMET, Philippe, G. , STACHEL, Shawn, R. , YANG, Wenjin , LU, Wanli , FAHR, Bruce
IPC分类号： C07D471/10 , A61K31/438 , A61P25/28
CPC分类号： C07D471/10
摘要： The present invention is directed to spiropiperidine compounds of formula (I) and tautomers thereof, which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
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8.发明公开AMINOMETHYL BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 有权阿尔茨海默氏病的治疗氨基甲基β-分泌酶抑制剂
公开(公告)号：EP1855679A2
公开(公告)日：2007-11-21
申请号：EP06718443.2
申请日：2006-01-13
申请人： Merck & Co., Inc.
发明人： COBURN, Craig, A. , NANTERMET, Philippe, G. , RAJAPAKSE, Hemaka, A. , SELNICK, Harold, G. , STAUFFER, Shaun, R.
IPC分类号： A61K31/4745 , C07D271/06
CPC分类号： C07D413/06 , C07D271/10
摘要： The present invention is directed to aminomethyl compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
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