发明公开
- 专利标题： VERFAHREN ZUR HERSTELLUNG VON OXAZOLEN DURCH KONDENSATION VON AROMATISCHEN ALDEHYDEN MIT ALFA-KETOXIMEN ZU N-OXIDEN UND NACHFOLGENDE REAKTION MIT AKTIVIERTEN SÄUREDERIVATEN
- 专利标题（英）： Method for the production of oxazoles by condensing aromatic aldehydes with a-ketoximes to n-oxides and then reacting the same with activated acid derivatives
- 专利标题（中）： 用于生产恶唑BY缩合ALFA-酮肟TO N氧化物和后续反应芳香醛与活性酸衍生物
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申请号： EP05817378.2申请日： 2005-12-01
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公开(公告)号： EP1828149A1公开(公告)日： 2007-09-05
- 发明人: HOLLA, Wolfgang , HOERLEIN, Rolf-Ludwig , KULITZSCHER, Berndt , LAUX, Wolfgang , STUEDEMANN, Thomas , TAPPERTZHOFEN, Christoph , SCHEFFER, Robert, J., H.
- 申请人： Sanofi-Aventis Deutschland GmbH
- 申请人地址： Brüningstrasse 50 65929 Frankfurt am Main DE
- 专利权人： Sanofi-Aventis Deutschland GmbH
- 当前专利权人： Sanofi-Aventis Deutschland GmbH
- 当前专利权人地址： Brüningstrasse 50 65929 Frankfurt am Main DE
- 优先权： DE102004060227 20041215
- 国际公布： WO2006066694 20060629
- 主分类号： C07D263/32
- IPC分类号： C07D263/32 ; A61K31/41 ; A61P3/00
摘要：
Disclosed is a method for producing oxazoles of formula IV by condensing aromatic aldehydes with a-ketoximes to N-oxides and then reacting the same with activated acid derivatives. The invention relates to a method for producing oxazoles by condensing aldehydes with a-ketoximes to N-oxides in the form of the salts thereof or as free bases and then reacting the same with activated acid derivatives so as to obtain oxazoles in the form of the salts thereof or as free bases.
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