发明公开
EP1831236A4 METHOD FOR THE PREPARATION OF 2'-DEOXY-2',2'-DIFLUOROCYTIDINE
审中-公开
VERFAHREN ZUR HERSTELLUNG VON 2'-脱氧-2'，2'-二氟胞嘧啶
- 专利标题： METHOD FOR THE PREPARATION OF 2'-DEOXY-2',2'-DIFLUOROCYTIDINE
- 专利标题（中）： VERFAHREN ZUR HERSTELLUNG VON 2'-脱氧-2'，2'-二氟胞嘧啶
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申请号： EP05823850申请日： 2005-12-29
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公开(公告)号： EP1831236A4公开(公告)日： 2013-11-20
- 发明人: LEE JAEHEON , PARK GHA SEUNG , LEE MOONSUB , BANG HYO-JEONG , LEE JAE CHUL , KIM CHEOL KYONG , CHOI CHANG-JU , KIM HAN KYONG , LEE HOE CHUL , CHANG YOUNG-KIL , LEE GWAN SUN
- 申请人： HANMI SCIENCE CO LTD
- 专利权人： HANMI SCIENCE CO LTD
- 当前专利权人： HANMI SCIENCE CO LTD
- 优先权： KR20040116316 2004-12-30; KR2005001954 2005-06-23
- 主分类号： C07H19/04
- IPC分类号： C07H19/04
摘要：
This invention relates to an improved method for stereoselectively preparing 2¢¥-deoxy-2¢¥,2¢¥-difluorocytidine of formula (I), which comprises the steps of reacting a 1-halo ribofuranose compound of formula (III) with a nucleobase of formula (IV) in a solvent to obtain a nucleoside of formula (II) with removing the silyl halide of formula (V) produced during the reaction; and deprotecting the nucleoside of formula (II) to obtain 2¢¥-deoxy-2¢¥,2¢¥-difluorocytidine of formula (I).
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