发明公开
EP1846034A4 AGENTS AND METHODS RELATED TO REDUCING RESISTANCE TO APOPTOSIS-INDUCING DEATH RECEPTOR AGONISTS
审中-公开
手段与方法进行抗打击诱导细胞凋亡的死亡受体激动剂还原
- 专利标题： AGENTS AND METHODS RELATED TO REDUCING RESISTANCE TO APOPTOSIS-INDUCING DEATH RECEPTOR AGONISTS
- 专利标题（中）： 手段与方法进行抗打击诱导细胞凋亡的死亡受体激动剂还原
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申请号： EP06734149申请日： 2006-01-31
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公开(公告)号： EP1846034A4公开(公告)日： 2010-11-10
- 发明人: ZHOU TONG , KIMBERLY ROBERT P
- 申请人： UAB RESEARCH FOUNDATION
- 专利权人： UAB RESEARCH FOUNDATION
- 当前专利权人： UAB RESEARCH FOUNDATION
- 优先权： US64943705 2005-02-02
- 主分类号： C12Q1/00
- IPC分类号： C12Q1/00 ; A61K38/00 ; A61K38/28 ; A61K39/395 ; C07H19/167 ; C07H19/173 ; C07K16/28 ; G01N33/50
摘要：
Provided herein is a method of reversing or preventing a target cell's resistance to a death receptor agonist. Also provided are methods of screening for biomarkers resistance of and monitoring resistance to death receptor agonists. Also provided are methods of selectively inducing apoptosis in a target cell, treating a subject with cancer, autoimmune or inflammatory diseases, comprising administering compositions provided herein. Further provided are compositions comprising agents that modulate CARD containing proteins.
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