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1.发明公开AGENTS AND METHODS RELATED TO REDUCING RESISTANCE TO APOPTOSIS-INDUCING DEATH RECEPTOR AGONISTS 审中-公开手段与方法进行抗打击诱导细胞凋亡的死亡受体激动剂还原
公开(公告)号：EP1846034A4
公开(公告)日：2010-11-10
申请号：EP06734149
申请日：2006-01-31
发明人： ZHOU TONG , KIMBERLY ROBERT P
IPC分类号： C12Q1/00 , A61K38/00 , A61K38/28 , A61K39/395 , C07H19/167 , C07H19/173 , C07K16/28 , G01N33/50
CPC分类号： G01N33/57492 , A61K39/39558 , A61K2039/505 , C07K16/2878 , C07K16/40 , C07K2317/34 , C12Q1/6886 , G01N33/574 , G01N33/6863 , G01N2333/70578 , G01N2333/7151 , G01N2333/914 , G01N2500/02 , G01N2800/44 , A61K2300/00
摘要： Provided herein is a method of reversing or preventing a target cell's resistance to a death receptor agonist. Also provided are methods of screening for biomarkers resistance of and monitoring resistance to death receptor agonists. Also provided are methods of selectively inducing apoptosis in a target cell, treating a subject with cancer, autoimmune or inflammatory diseases, comprising administering compositions provided herein. Further provided are compositions comprising agents that modulate CARD containing proteins.
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公开(公告)号：EP1028626A4
公开(公告)日：2001-05-16
申请号：EP98957705
申请日：1998-11-06
发明人： MOUNTZ JOHN D , ZHANG HUANG-GE , ZHOU TONG , EDWARDS CARL K
IPC分类号： C12N15/09 , A61K35/76 , A61K38/00 , A61K38/19 , A61K39/39 , A61K48/00 , A61P39/00 , C07K1/00 , A61K38/17
CPC分类号： A61K48/00 , A61K38/191 , A61K39/39 , A61K2039/53 , A61K2039/55522
摘要： The present invention provides a method of increasing adenoviral gene expression in a tissue of an animal, comprising the step of administering to said animal a pharmacologically effective dose of tumor necrosis factor binding protein. Also provided is a various method of method of reducing an inflammatory response associated with adenoviral administration in a tissue of an animal, comprising the step of administering to said animal a pharmacologically effective dose of tumor necrosis factor binding protein.
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3.发明公开AN ANTIBODY SELECTIVE FOR A TUMOR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGAND RECEPTOR AND USES THEREOF 有权为肿瘤坏死因子相似，细胞凋亡诱导配体受体的选择性抗体及其应用
公开(公告)号：EP1287035A4
公开(公告)日：2004-09-29
申请号：EP01932876
申请日：2001-05-02
IPC分类号： C12N15/02 , A61K31/337 , A61K39/395 , A61K45/06 , A61P1/04 , A61P3/10 , A61P5/18 , A61P7/06 , A61P9/10 , A61P13/12 , A61P15/00 , A61P17/00 , A61P21/04 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/08 , A61P43/00 , C07D305/14 , C07H21/02 , C07K16/00 , C07K16/28 , C07K16/30 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/09 , C12P21/08 , A01N43/04
CPC分类号： A61K39/39558 , A61K2039/505 , C07K16/2878 , C07K16/30 , C07K2317/24 , C07K2317/73 , C07K2319/00 , C07K2319/30 , G01N33/6863
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4.发明公开COMBINATIONS OF ANTIBODIES SELECTIVE FOR A TUMOR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGAND RECEPTOR AND OTHER THERAPEUTIC AGENTS 有权组合功能，用于相关凋亡诱导配体受体和其他治疗药剂肿瘤坏死因子，
公开(公告)号：EP1506285A4
公开(公告)日：2007-09-26
申请号：EP02795556
申请日：2002-10-25
发明人： ZHOU TONG , ICHIKAWA KIMIHISA , KIMBERLY ROBERT P , KOOPMAN WILLIAM J , OSHUMI JUN , LOBUGLIO ALBERT F , BUCHSBAUM DONALD J
IPC分类号： C12N15/09 , A61K31/337 , A61K31/404 , A61K31/519 , A61K31/704 , A61K35/12 , A61K38/00 , A61K39/395 , A61K41/00 , A61K45/00 , A61K45/06 , A61P1/00 , A61P3/10 , A61P5/14 , A61P7/02 , A61P7/04 , A61P7/06 , A61P9/10 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P21/04 , A61P25/00 , A61P29/00 , A61P31/04 , A61P31/12 , A61P33/06 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P37/08 , C07K16/28 , C12N1/00 , C07K16/26
CPC分类号： C07K16/2878 , A61K31/337 , A61K31/519 , A61K41/00 , A61K45/06 , A61K2039/505 , A61K2300/00
摘要： An antibody of the invention interacts with human DR5 or with human DR4 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Methods and uses for the antibodies, optionally in combination with various therapeutic agents, are detailed, including treatment of apoptosis-related disease and treatment of dysregulated cell growth.
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公开(公告)号：EP2788377A4
公开(公告)日：2015-11-18
申请号：EP12847223
申请日：2012-11-09
发明人： ZHOU TONG , BUCHSBAUM DONALD J , SHEN ENYUN , CHEN XIAN
IPC分类号： C07K16/28 , A61K31/517 , A61K39/00 , A61K39/395 , A61K45/06 , A61P35/00 , C07K16/32 , G01N33/574
CPC分类号： C07K16/2863 , A61K31/517 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/32 , G01N33/574
摘要： Provided herein are antibodies specific for HER3. Also provided are methods of treating cancer in a subject comprising administering an effective amount of the antibodies described herein to the subject.
摘要翻译： 本文提供的是针对HER3的抗体。 还提供了在受试者中治疗癌症的方法，包括向受试者施用有效量的本文所述的抗体。
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6.发明公开AN ANTIBODY SELECTIVE FOR A TUMOR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGAND RECEPTOR AND USES THEREOF 有权ONE FOR诱导细胞凋亡，肿瘤坏死因子相关的配受体的选择性抗体及其用途
公开(公告)号：EP1506011A4
公开(公告)日：2006-07-12
申请号：EP02786649
申请日：2002-11-01
IPC分类号： C12N15/09 , A61K31/337 , A61K31/519 , A61K31/704 , A61K39/395 , A61K41/00 , A61K45/00 , A61K45/06 , A61P3/10 , A61P5/44 , A61P7/06 , A61P9/00 , A61P9/10 , A61P11/06 , A61P13/12 , A61P17/00 , A61P21/04 , A61P25/28 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12N15/63 , C12P21/08 , C07H21/04 , C12P21/06
CPC分类号： C07K16/2878 , A61K31/337 , A61K31/519 , A61K39/39541 , A61K41/00 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2319/00 , C07K2319/30 , A61K2300/00
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