发明公开
EP1848806A1 ANTI-T CELL AND AUTOANTIGEN TREATMENT OF AUTOIMMUNE DISEASE
审中-公开
ANTI-T细胞和自身免疫性疾病的自体抗原治疗
- 专利标题： ANTI-T CELL AND AUTOANTIGEN TREATMENT OF AUTOIMMUNE DISEASE
- 专利标题（中）： ANTI-T细胞和自身免疫性疾病的自体抗原治疗
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申请号： EP06701862.2申请日： 2006-02-06
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公开(公告)号： EP1848806A1公开(公告)日： 2007-10-31
- 发明人: JEVNIKAR, Anthony , MA, Shengwu , AINLEY, William, Michael , MERLO, Donald Joseph , RUSSELL, Sean, Michael , ARMSTRONG, Janna, M.
- 申请人： Dow AgroSciences LLC , Plantigen Inc.
- 申请人地址： 9330 Zionsville Road Indianapolis, Indiana 46268 US
- 专利权人： Dow AgroSciences LLC,Plantigen Inc.
- 当前专利权人： Dow AgroSciences LLC,Plantigen Inc.
- 当前专利权人地址： 9330 Zionsville Road Indianapolis, Indiana 46268 US
- 代理机构： Davies, Jonathan Mark
- 优先权： US649565P 20050204
- 国际公布： WO2006081669 20060810
- 主分类号： C12N15/82
- IPC分类号： C12N15/82 ; C12N15/60 ; C12N15/24 ; A61P3/10 ; A61K31/52 ; A61K31/519 ; A61K39/395 ; A61K39/00 ; A61K38/20 ; A61K38/13
摘要：
The invention is directed to a new method for the treatment of new onset Type I diabetes in mammals or for the treatment of pre-Type I diabetic mammals where the method comprises administering (a) anti-T cell therapy to the mammal and administering (b) an autoantigen and optional mucosal antigen composition, wherein (a) and (b) are administered concurrently or sequentially Exemplified is a treatment using a mixture of anti-CD3 antibodies, a glutamic acid decarboxylase (GAD) autoantigen, and an immunoregulatory cytokine Canme GAD sequences are also disclosed.
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