发明公开
EP1852422A2 Nitrosated and nitorsylated alpha-andrenergic receptor antagonist compounds, compositions and their uses
失效
亚硝化和亚硝基化andrenergische的α-受体拮抗剂化合物，它们的组合物，及其用途
- 专利标题： Nitrosated and nitorsylated alpha-andrenergic receptor antagonist compounds, compositions and their uses
- 专利标题（中）： 亚硝化和亚硝基化andrenergische的α-受体拮抗剂化合物，它们的组合物，及其用途
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申请号： EP07011814.6申请日： 1997-01-28
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公开(公告)号： EP1852422A2公开(公告)日： 2007-11-07
- 发明人: Garvey, David S. , Schroeder, Joseph, D. , Saenz de Tejada, Inigo
- 申请人： Nitromed, Inc.
- 申请人地址： 125 Spring Street Lexington, MA 02421-7801 US
- 专利权人： Nitromed, Inc.
- 当前专利权人： Nitromed, Inc.
- 当前专利权人地址： 125 Spring Street Lexington, MA 02421-7801 US
- 代理机构： Wright, Robert Gordon McRae
- 优先权： US595732 19960202; US714313 19960918
- 主分类号： C07D233/20
- IPC分类号： C07D233/20 ; A61K31/4164 ; A61P15/10
摘要：
Disclosed are nitrosated and nitrosylated α-adrenergic receptor antagonists, compositions of an α-adrenergic receptor antagonist (α-antagonist), which can optionally be substituted with at least one NO or NO 2 moiety, and a compound that donates, transfers or releases nitric oxide as a charged species, i.e., nitrosonium (NO + ) or nitroxyl (NO - ), or as the neutral species, nitric oxide (NO.); and uses for each of them in treating human impotence or erectile dysfunction.
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