公开(公告)号：EP1852422A3

公开(公告)日：2007-11-21

申请号：EP07011814.6

申请日：1997-01-28

申请人： Nitromed, Inc.

发明人： Garvey, David S. ,  Schroeder, Joseph, D. ,  Saenz de Tejada, Inigo

IPC分类号： C07D239/95 ,  C07D233/20 ,  C07D233/28 ,  C07D459/00 ,  C07D311/22 ,  C07D335/06 ,  C07D295/08 ,  A61K31/495 ,  A61K31/135 ,  A61K31/435

CPC分类号： C07D459/00 ,  C07C381/00 ,  C07D211/62 ,  C07D233/24 ,  C07D239/95 ,  C07D401/04 ,  C07D405/12 ,  Y10S514/929

摘要： Disclosed are nitrosated and nitrosylated α-adrenergic receptor antagonists, compositions of an α-adrenergic receptor antagonist (α-antagonist), which can optionally be substituted with at least one NO or NO 2 moiety, and a compound that donates, transfers or releases nitric oxide as a charged species, i.e., nitrosonium (NO + ) or nitroxyl (NO - ), or as the neutral species, nitric oxide (NO.); and uses for each of them in treating human impotence or erectile dysfunction.

公开(公告)号：EP1852422A2

公开(公告)日：2007-11-07

申请号：EP07011814.6

申请日：1997-01-28

申请人： Nitromed, Inc.

发明人： Garvey, David S. ,  Schroeder, Joseph, D. ,  Saenz de Tejada, Inigo

IPC分类号： C07D233/20 ,  A61K31/4164 ,  A61P15/10

CPC分类号： C07D459/00 ,  C07C381/00 ,  C07D211/62 ,  C07D233/24 ,  C07D239/95 ,  C07D401/04 ,  C07D405/12 ,  Y10S514/929

摘要： Disclosed are nitrosated and nitrosylated α-adrenergic receptor antagonists, compositions of an α-adrenergic receptor antagonist (α-antagonist), which can optionally be substituted with at least one NO or NO 2 moiety, and a compound that donates, transfers or releases nitric oxide as a charged species, i.e., nitrosonium (NO + ) or nitroxyl (NO - ), or as the neutral species, nitric oxide (NO.); and uses for each of them in treating human impotence or erectile dysfunction.

摘要翻译： 本发明公开了亚硝化和亚硝酰化±肾上腺素能受体拮抗剂，一个±肾上腺素能受体拮抗剂的组合物（±拮抗剂），其可以与至少一种的NO或NO 2基团的化合物，以及任选地被substituiertem做捐赠，转移或释放一 氧化物作为带电物质，即，亚硝鎓（NO +）或硝酰基（NO - ），或作为中性物质，一氧化氮（NO）; 并在治疗人类阳痿或勃起功能障碍的用途为他们每个人。