发明公开
EP1852510A1 5-SUBSTITUTED HYDANTOIN RACEMASE, DNA ENCODING THE SAME, RECOMBINANT DNA, TRANSFORMED CELL, AND PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE N-CARBAMYLAMINO ACID OR OPTICALLY ACTIVE AMINO ACID
审中-公开
5-取代的乙内酰脲消旋酶编码DNA，重组DNA，转化细胞及其制造方法光学活性N-CARBAMYLAMINOSÄUREOR光学活性氨基
- 专利标题： 5-SUBSTITUTED HYDANTOIN RACEMASE, DNA ENCODING THE SAME, RECOMBINANT DNA, TRANSFORMED CELL, AND PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE N-CARBAMYLAMINO ACID OR OPTICALLY ACTIVE AMINO ACID
- 专利标题（中）： 5-取代的乙内酰脲消旋酶编码DNA，重组DNA，转化细胞及其制造方法光学活性N-CARBAMYLAMINOSÄUREOR光学活性氨基
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申请号： EP06712435.4申请日： 2006-01-26
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公开(公告)号： EP1852510A1公开(公告)日： 2007-11-07
- 发明人: NISHI, Kenichi , YANAGISAWA, Satohiro , NANBA, Hirokazu , UEDA, Makoto , NORO, Naoto
- 申请人： Kaneka Corporation
- 申请人地址： 2-4, Nakanoshima 3-chome Kita-ku Osaka-shi, Osaka 530-8288 JP
- 专利权人： Kaneka Corporation
- 当前专利权人： Kaneka Corporation
- 当前专利权人地址： 2-4, Nakanoshima 3-chome Kita-ku Osaka-shi, Osaka 530-8288 JP
- 代理机构： Vossius & Partner
- 优先权： JP2005022802 20050131
- 国际公布： WO2006080409 20060803
- 主分类号： C12N15/61
- IPC分类号： C12N15/61 ; C12N1/21 ; C12N9/90 ; C12P17/10 ; C12P41/00
摘要：
Disclosed are a novel hydantoin racemase and a process for producing an optically active N-carbamylamino acid or an optically active amino acid using the hydantoin racemase. A novel hydantoin racemase isolated and purified from Bacillus sp. Strain KNK519HR; a gene encoding the hydantoin racemase; a recombinant plasmid having the gene introduced therein; a transformant having the hydantoin racemase gene introduced therein; and a process for producing an optically active N-carbamylamino acid or an optically active amino acid characterized in that a 5-substituted hydantoin compound is treated in the presence of hydantoinase and N-carbamylamino acid amidohydolase as well as the hydantoin racemase.
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