发明公开
EP1856053A1 CINNAMIDE AND HYDROCINNAMIDE DERIVATIVES WITH RAF-KINASE INHIBITORY ACTIVITY
审中-公开
与Raf激酶抑制活性CINNAMID-和苯丙衍生物
- 专利标题： CINNAMIDE AND HYDROCINNAMIDE DERIVATIVES WITH RAF-KINASE INHIBITORY ACTIVITY
- 专利标题（中）： 与Raf激酶抑制活性CINNAMID-和苯丙衍生物
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申请号： EP06718548.8申请日： 2006-01-12
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公开(公告)号： EP1856053A1公开(公告)日： 2007-11-21
- 发明人: ADAMS, Ruth, S. , CALDERWOOD, Emily, F. , GOULD, Alexandra, E. , GREENSPAN, Paul, D. , LAMARCHE, Matthew, J. , TIAN, Yuan , VOS, Tricia, J.
- 申请人： MILLENNIUM PHARMACEUTICALS, INC.
- 申请人地址： 40 Landsdowne Street Cambridge, MA 02139 US
- 专利权人： MILLENNIUM PHARMACEUTICALS, INC.
- 当前专利权人： MILLENNIUM PHARMACEUTICALS, INC.
- 当前专利权人地址： 40 Landsdowne Street Cambridge, MA 02139 US
- 代理机构： Harris, Jennifer Lucy
- 优先权： US643928P 20050114; US710635P 20050823
- 国际公布： WO2006076706 20060720
- 主分类号： C07D213/81
- IPC分类号： C07D213/81 ; C07D213/79 ; C07D213/73 ; C07D213/68 ; C07D237/24 ; C07D239/34 ; C07D233/70 ; C07D241/44 ; C07D401/12 ; C07D413/12 ; C07D401/14 ; C07D231/18 ; C07D261/12 ; C07D277/64 ; A61P35/00
摘要：
The present invention provides novel cinnamide compounds of formula (I) useful as inhibitors of raf -protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and use thereof in the treatment of various cell proliferative diseases, wherein the rings B and C, G and L are as defined herein.
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