发明授权
- 专利标题： QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS
- 专利标题（中）： 喹唑啉衍生物作为酪氨酸激酶抑制剂
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申请号： EP06709888.9申请日： 2006-02-24
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公开(公告)号： EP1856095B1公开(公告)日： 2011-08-24
- 发明人: HALSALL, Christopher Thomas , HENNEQUIN, Laurent Francois Andre , PLOWRIGHT, Alleyn Thomas , STOREY, Richard , LENNON, Kieran
- 申请人： AstraZeneca AB
- 申请人地址： 151 85 Södertälje SE
- 专利权人： AstraZeneca AB
- 当前专利权人： AstraZeneca AB
- 当前专利权人地址： 151 85 Södertälje SE
- 代理机构： Nelson, Michael Andrew
- 优先权： GB0504018 20050226; GB0506657 20050331; GB0524001 20051125
- 国际公布： WO2006090163 20060831
- 主分类号： C07D401/12
- IPC分类号： C07D401/12 ; A61K31/517 ; A61P35/00
摘要：
The invention concerns quinazoline derivatives of the Formula (I), or pharmaceutically acceptable salts thereof: I wherein each of R1, R2, R3, R4 and m are as defined in the description; processes for their preparation; pharmaceutical compositions containing them and their use in the manufacture of a medicament for providing an anti-proliferative effect. The quinazoline derivatives of Formula (I) are expected to be useful in the treatment of diseases such as certain cancers mediated by erbB receptor tyrosine kinases, particularly EGFR tyrosine kinase.
公开/授权文献
- EP1856095A1 QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS 公开/授权日：2007-11-21
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