公开(公告)号：EP3837017A1

公开(公告)日：2021-06-23

申请号：EP19779577.6

申请日：2019-08-15

申请人： Astrazeneca AB

发明人： GELLERT, Paul ,  HILL, Kathryn ,  STOREY, Richard

IPC分类号： A61P35/00 ,  A61K47/56 ,  A61K47/60 ,  A61K49/12 ,  A61K49/14 ,  B82Y5/00 ,  C07D211/22 ,  C08G83/00 ,  A61K31/445 ,  C08G69/10

公开(公告)号：EP2027114A1

公开(公告)日：2009-02-25

申请号：EP07732795.5

申请日：2007-05-14

申请人： AstraZeneca AB

发明人： SEPENDA, George, Joseph ,  STOREY, Richard

IPC分类号： C07D403/12 ,  C07F9/09 ,  A61K31/661 ,  A61P35/00

CPC分类号： C07D403/12 ,  C07F9/65583

摘要： The present invention relates to a novel co-crystal of 2-{cthyl[3-( {4-[(5- {2-[(3-fluorophenyl)amino]-2-oxoethyl}-IH-pyrazol-3-yl)amino]quinazolin-7- yl}oxy)propyl]amino} ethyl dihydrogen phosphate (AZDl 152) which is an aurora kinase inhibitor that is useful in the treatment of hyperproliferative diseases such as cancer.

摘要翻译： 本发明涉及2- {乙基[3 - （{4 - [（5- {2 - [（3-氟苯基）氨基] -2-氧代乙基} -1H-吡唑-3-基 ）氨基]喹唑啉-7-基}氧基）丙基]氨基}乙基磷酸二氢盐（AZD1152），其为用于治疗过度增殖性疾病如癌症的极光激酶抑制剂。

公开(公告)号：EP1856095B1

公开(公告)日：2011-08-24

申请号：EP06709888.9

申请日：2006-02-24

申请人： AstraZeneca AB

发明人： HALSALL, Christopher Thomas ,  HENNEQUIN, Laurent Francois Andre ,  PLOWRIGHT, Alleyn Thomas ,  STOREY, Richard ,  LENNON, Kieran

IPC分类号： C07D401/12 ,  A61K31/517 ,  A61P35/00

CPC分类号： C07D401/12

摘要： The invention concerns quinazoline derivatives of the Formula (I), or pharmaceutically acceptable salts thereof: I wherein each of R1, R2, R3, R4 and m are as defined in the description; processes for their preparation; pharmaceutical compositions containing them and their use in the manufacture of a medicament for providing an anti-proliferative effect. The quinazoline derivatives of Formula (I) are expected to be useful in the treatment of diseases such as certain cancers mediated by erbB receptor tyrosine kinases, particularly EGFR tyrosine kinase.

公开(公告)号：EP1856095A1

公开(公告)日：2007-11-21

申请号：EP06709888.9

申请日：2006-02-24

申请人： AstraZeneca AB

发明人： HALSALL, Christopher Thomas ,  HENNEQUIN, Laurent Francois Andre ,  PLOWRIGHT, Alleyn Thomas ,  STOREY, Richard ,  LENNON, Kieran

IPC分类号： C07D401/12 ,  A61K31/517 ,  A61P35/00

CPC分类号： C07D401/12

摘要： The invention concerns quinazoline derivatives of the Formula (I), or pharmaceutically acceptable salts thereof: I wherein each of R1, R2, R3, R4 and m are as defined in the description; processes for their preparation; pharmaceutical compositions containing them and their use in the manufacture of a medicament for providing an anti-proliferative effect. The quinazoline derivatives of Formula (I) are expected to be useful in the treatment of diseases such as certain cancers mediated by erbB receptor tyrosine kinases, particularly EGFR tyrosine kinase.