发明公开
EP1862447A3 Novel processes for preparing sertraline hydrochloride crystalline forms
审中-公开
Neue Verfahren zur Herstellung kristalliner Formen von Sertralinhydrochlorid
- 专利标题： Novel processes for preparing sertraline hydrochloride crystalline forms
- 专利标题（中）： Neue Verfahren zur Herstellung kristalliner Formen von Sertralinhydrochlorid
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申请号： EP07005549.6申请日： 2007-03-19
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公开(公告)号： EP1862447A3公开(公告)日： 2008-09-10
- 发明人: Reddy, Bandi Parthasaradhi , Reddy, Kura Rathnakar , Reddy, Rapolu Raji , Reddy, Dasari Muralidhara , Reddy, Kesireddy Subash Chander
- 申请人： Hetero Drugs Limited
- 申请人地址： Hetero House, 8-3-166/7/1, Erragadda Hyderabad 500 018, Andhrapradesh IN
- 专利权人： Hetero Drugs Limited
- 当前专利权人： Hetero Drugs Limited
- 当前专利权人地址： Hetero House, 8-3-166/7/1, Erragadda Hyderabad 500 018, Andhrapradesh IN
- 代理机构： Green, Mark Charles
- 优先权： US444683 20060601
- 主分类号： C07C209/84
- IPC分类号： C07C209/84 ; C07C211/42
摘要：
The present invention discloses novel and improved processes for preparation of sertraline hydrochloride crystalline form II. Thus, for example, sertraline free base is dissolved in isoamyl alcohol at 25 - 30°C, pH of the mass is adjusted to 2.0 with conc. hydrochloric acid (36%) at 25 - 30°C and then stirred for 14 hours at 25 - 30°C. Filtered the solid and dried at 65°C for 4 hours to give sertraline hydrochloride crystalline form II. The present invention also provides a novel process for preparation of sertraline hydrochloride crystalline form 1.
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