公开(公告)号：EP2033947A1

公开(公告)日：2009-03-11

申请号：EP08169272.5

申请日：2007-03-19

申请人： Hetero Drugs Limited

发明人： Reddy, Bandi Parthasaradhi ,  Reddy, Kura Rathnakar ,  Reddy, Rapolu Raji ,  Reddy, Dasari Muralidhara ,  Reddy, Kesireddy Subash Chander

IPC分类号： C07C209/84 ,  C07C211/42

CPC分类号： C07C209/84 ,  C07C2602/10 ,  C07C211/42

摘要： Process for preparing sertraline hydrochloride crystalline form I comprising (a) adding sertraline free base or sertraline mandelate to n-amyl alcohol, (b) adding hydrochloric acid at 25 °C or below, and (c) isolating sertraline hydrochloride crystalline form I.

摘要翻译： （a）将舍曲林游离碱或舍曲林扁桃酸盐加入到正戊醇中，（b）在25℃或更低温度下加入盐酸，和（c）分离舍曲林盐酸盐结晶形式I.

公开(公告)号：EP1862447A3

公开(公告)日：2008-09-10

申请号：EP07005549.6

申请日：2007-03-19

申请人： Hetero Drugs Limited

发明人： Reddy, Bandi Parthasaradhi ,  Reddy, Kura Rathnakar ,  Reddy, Rapolu Raji ,  Reddy, Dasari Muralidhara ,  Reddy, Kesireddy Subash Chander

IPC分类号： C07C209/84 ,  C07C211/42

CPC分类号： C07C209/84 ,  C07C2602/10 ,  C07C211/42

摘要： The present invention discloses novel and improved processes for preparation of sertraline hydrochloride crystalline form II. Thus, for example, sertraline free base is dissolved in isoamyl alcohol at 25 - 30°C, pH of the mass is adjusted to 2.0 with conc. hydrochloric acid (36%) at 25 - 30°C and then stirred for 14 hours at 25 - 30°C. Filtered the solid and dried at 65°C for 4 hours to give sertraline hydrochloride crystalline form II. The present invention also provides a novel process for preparation of sertraline hydrochloride crystalline form 1.

摘要翻译： 本发明公开了制备盐酸舍曲林结晶II的新型改进方法。 因此，例如，将舍曲林游离碱溶解在异戊醇中，在25-30℃下，将质量的pH调节至2.0， 盐酸（36％），25-30℃，然后在25-30℃下搅拌14小时。 过滤固体并在65℃下干燥4小时，得到盐酸舍曲林结晶II型。 本发明还提供了一种制备盐酸舍曲林结晶形式的新方法。

公开(公告)号：EP2213676A1

公开(公告)日：2010-08-04

申请号：EP09177637.7

申请日：2004-11-01

申请人： Hetero Drugs Limited

发明人： Reddy, Bandi Parthasaradhi ,  Reddy, Kura Rathnakar ,  Reddy, Rapolu Raji ,  Reddy, Dasari Muralidhara ,  Murali, Nagabelli

IPC分类号： C07D501/04 ,  C07D501/22

CPC分类号： C07D501/22 ,  C07F7/188

摘要： A process for preparing (6R,7R)-7-[2-amino-2-(4-hydroxyphenyl) acetamido]-3-[(Z)-propenyl]-3-cephem-4-carboxylic acid of formula I (cefprozil) or its hydrate, or a pharmaceutically acceptable salt thereof.

摘要翻译： 制备式I的（6R，7R）-7- [2-氨基-2-（4-羟基苯基）乙酰氨基] -3 - [（Z） - 丙烯基] -3-头孢烯-4-羧酸的方法（头孢丙烯 ）或其水合物，或其药学上可接受的盐。

公开(公告)号：EP2033946A1

公开(公告)日：2009-03-11

申请号：EP08169246.9

申请日：2007-03-19

申请人： Hetero Drugs Limited

发明人： Reddy, Bandi Parthasaradhi ,  Reddy, Kura Rathnakar ,  Reddy, Rapolu Raji ,  Reddy, Dasari Muralidhara ,  Reddy, Kesireddy Subash Chander

IPC分类号： C07C209/84 ,  C07C211/42

CPC分类号： C07C209/84 ,  C07C2602/10 ,  C07C211/42

摘要： Process for the preparation of sertraline hydrochloride crystalline form II comprising (a) stirring sertraline hydrochloride in a solvent selected from isoamyl alcohol, tert-amyl alcohol and an ester formed by isoamyl alcohol and C 1 -C 3 -carboxylic acid for a time sufficient to conversion to sertraline hydrochloride crystalline form II; and (b) isolating sertraline hydrochloride crystalline form II.

摘要翻译： 制备盐酸舍曲林结晶II的方法，其包括（a）在选自异戊醇，叔戊醇和由异戊醇和C 1 -C 3 - 羧酸形成的酯的溶剂中搅拌舍曲林盐酸盐一段时间， 转化为盐酸舍曲林结晶II型; 和（b）分离盐酸舍曲林结晶II型。

公开(公告)号：EP1862447A2

公开(公告)日：2007-12-05

申请号：EP07005549.6

申请日：2007-03-19

申请人： Hetero Drugs Limited

发明人： Reddy, Bandi Parthasaradhi ,  Reddy, Kura Rathnakar ,  Reddy, Rapolu Raji ,  Reddy, Dasari Muralidhara ,  Reddy, Kesireddy Subash Chander

IPC分类号： C07C209/84 ,  C07C211/42

CPC分类号： C07C209/84 ,  C07C2602/10 ,  C07C211/42

摘要： The present invention discloses novel and improved processes for preparation of sertraline hydrochloride crystalline form II. Thus, for example, sertraline free base is dissolved in isoamyl alcohol at 25 - 30°C, pH of the mass is adjusted to 2.0 with conc. hydrochloric acid (36%) at 25 - 30°C and then stirred for 14 hours at 25 - 30°C. Filtered the solid and dried at 65°C for 4 hours to give sertraline hydrochloride crystalline form II. The present invention also provides a novel process for preparation of sertraline hydrochloride crystalline form 1.