发明公开
- 专利标题： A NOVEL CRYSTALLINE FORM OF RUPATADINE FREE BASE
- 专利标题（中）： 他定的游离碱的新晶型
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申请号： EP05742906.0申请日： 2005-04-01
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公开(公告)号： EP1863788A1公开(公告)日： 2007-12-12
- 发明人: PARTHASARADHI REDDY, Bandi , RATHNAKAR REDDY, Kura, , RAJI REDDY, Rapolu, , MURALIDHARA REDDY, D., , SUBASH CHANDER REDDY, K.,
- 申请人： Hetero Drugs Limited
- 申请人地址： Hetero House, 8-3-166/7/1, Erragadda Hyderabad 500 018, Andhrapradesh IN
- 专利权人： Hetero Drugs Limited
- 当前专利权人： Hetero Drugs Limited
- 当前专利权人地址： Hetero House, 8-3-166/7/1, Erragadda Hyderabad 500 018, Andhrapradesh IN
- 代理机构： Green, Mark Charles
- 国际公布： WO2006103688 20061005
- 主分类号： C07D401/00
- IPC分类号： C07D401/00 ; A61K31/445
摘要：
The present invention relates to a novel crystalline form of rupatadine free base, process for its preparation and to a pharmaceutical composition containing it. In accordance with the present invention rupatadine is suspended in n-hexane, n-heptane, cyclohexane, diethyl ether or diisopropyl ether, stirred for at least 1 hour, filtered the solid and dried to give crystalline rupatadine form-B. The isolation of novel rupatadine free base as crystalline form-B may be useful as a purification of rupatadine or a salt thereof.
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