公开(公告)号：EP1863788A1

公开(公告)日：2007-12-12

申请号：EP05742906.0

申请日：2005-04-01

申请人： Hetero Drugs Limited

发明人： PARTHASARADHI REDDY, Bandi ,  RATHNAKAR REDDY, Kura, ,  RAJI REDDY, Rapolu, ,  MURALIDHARA REDDY, D., ,  SUBASH CHANDER REDDY, K.,

IPC分类号： C07D401/00 ,  A61K31/445

CPC分类号： C07D401/14

摘要： The present invention relates to a novel crystalline form of rupatadine free base, process for its preparation and to a pharmaceutical composition containing it. In accordance with the present invention rupatadine is suspended in n-hexane, n-heptane, cyclohexane, diethyl ether or diisopropyl ether, stirred for at least 1 hour, filtered the solid and dried to give crystalline rupatadine form-B. The isolation of novel rupatadine free base as crystalline form-B may be useful as a purification of rupatadine or a salt thereof.