发明公开
EP1863819A2 DIAZABICYCLIC ARYL DERIVATIVES AND THEIR USE AS CHINOLINERGIC LIGANDS AT THE NICOTINIC ACETYLCHOLINE RECEPTORS
有权
二氮杂双环芳基衍生物和它们作为配位体CHINOLINERGISCHE烟碱乙酰胆碱受体使用
- 专利标题： DIAZABICYCLIC ARYL DERIVATIVES AND THEIR USE AS CHINOLINERGIC LIGANDS AT THE NICOTINIC ACETYLCHOLINE RECEPTORS
- 专利标题（中）： 二氮杂双环芳基衍生物和它们作为配位体CHINOLINERGISCHE烟碱乙酰胆碱受体使用
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申请号： EP06708216.4申请日： 2006-02-13
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公开(公告)号： EP1863819A2公开(公告)日： 2007-12-12
- 发明人: PETERS, Dan , TIMMERMANN, Daniel, B. , OLSEN, Gunnar, M. , NIELSEN, Elsebet, Østergaard , DYHRING, Tino
- 申请人： NEUROSEARCH A/S
- 申请人地址： Pederstrupvej 93 2750 Ballerup DK
- 专利权人： NEUROSEARCH A/S
- 当前专利权人： NEUROSEARCH A/S
- 当前专利权人地址： Pederstrupvej 93 2750 Ballerup DK
- 优先权： DK200500230 20050216; US653491P 20050217; DK200501723 20051206
- 国际公布： WO2006087306 20060824
- 主分类号： C07D487/08
- IPC分类号： C07D487/08 ; C07D471/08 ; A61K31/551 ; A61P25/28
摘要：
This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
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