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1.发明公开NOVEL INDOLYL-OXADIAZOLYL-DIAZABICYCLONONANE DERIVATIVES AND THEIR MEDICAL AND DIAGNOSTICAL USE 审中-公开新的吲哚基 - 二唑，diazabicyclononan衍生物及其医疗和诊断用途
公开(公告)号：EP2389181A1
公开(公告)日：2011-11-30
申请号：EP10701355.9
申请日：2010-01-25
申请人： NeuroSearch A/S
发明人： PETERS, Dan , TIMMERMANN, Daniel, B. , DYHRING, Tino , CHRISTENSEN, Jeppe, Kejser , NIELSEN, Elsebet, Østergaard
IPC分类号： A61K31/551 , C07D471/08 , A61P25/00
CPC分类号： C07D413/14 , A61K51/0468 , C07D471/08
摘要： This invention relates to novel indolyl-oxadiazolyl-diazabicyclononane derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
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2.发明授权DIAZABICYCLIC ARYL DERIVATIVES AND THEIR USE AS CHINOLINERGIC LIGANDS AT THE NICOTINIC ACETYLCHOLINE RECEPTORS 有权二氮杂双环芳基衍生物和它们作为配位体CHINOLINERGISCHE烟碱乙酰胆碱受体使用
公开(公告)号：EP1863819B1
公开(公告)日：2011-01-12
申请号：EP06708216.4
申请日：2006-02-13
申请人： NeuroSearch A/S
发明人： PETERS, Dan , TIMMERMANN, Daniel, B. , OLSEN, Gunnar, M. , NIELSEN, Elsebet, Østergaard , DYHRING, Tino
IPC分类号： C07D487/08 , C07D471/08 , A61K31/551 , A61P25/28
CPC分类号： C07D471/08 , C07D487/08
摘要： This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
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3.发明公开N-ARYL-N-PIPERIDIN-4-YL-PROPIONAMIDE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS 审中-公开N-芳基-N-哌啶-4-基 - 丙酰胺衍生物及其作为单胺神经递质再摄取抑制剂
公开(公告)号：EP2234616A1
公开(公告)日：2010-10-06
申请号：EP08861581.0
申请日：2008-12-18
申请人： NeuroSearch A/S
IPC分类号： A61K31/4468 , C07D211/58 , A61P25/04 , A61P25/06 , A61P25/18 , A61P25/24 , A61P25/22 , A61P25/28 , A61P25/16 , A61P25/32 , A61P25/34 , A61P25/36 , A61P19/02 , A61P19/10 , A61P3/04
CPC分类号： A61K31/4468 , C07D211/58
摘要： This invention relates to /\/-aryl-/\/-piperidin-4-yl-propionannide derivatives for use as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy, such as for the treatment of pain, and to pharmaceutical compositions comprising the compounds, and to novel compounds.
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4.发明公开NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL PYRIMIDINYL DERIVATIVES AND THEIR MEDICAL USE 审中-公开NEW 1,4-二氮杂双环[3.2.2] NONYLPYRIMIDINYLDERIVATE及其医学用途
公开(公告)号：EP2049538A1
公开(公告)日：2009-04-22
申请号：EP07729593.9
申请日：2007-05-29
申请人： NeuroSearch A/S
发明人： PETERS, Dan , OLSEN, Gunnar, M. , NIELSEN, Elsebet, Østergaard , TIMMERMANN, Daniel, B. , LOECHEL, Steven, Charles
IPC分类号： C07D471/08 , A61K31/551 , A61P25/00
CPC分类号： C07D471/08
摘要： This invention relates to a novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivative and its use in the manufacture of pharmaceutical compositions. The compound of the invention is found to be a cholinergic ligand at the nicotinic acetylcholine receptors. Due to its pharmacological profile the compound of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
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5.发明公开NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONANE DERIVATIVES AND THEIR MEDICAL USE 有权新的1,4-二氮杂双环[3.2.2]壬烷衍生物及其医药用途
公开(公告)号：EP2029594A1
公开(公告)日：2009-03-04
申请号：EP07729313.2
申请日：2007-05-21
申请人： NEUROSEARCH A/S
发明人： PETERS, Dan , OLSEN, Gunnar, M. , NIELSEN, Elsebet, Østergaard , TIMMERMANN, Daniel, B. , LOECHEL, Steven, Charles , CHRISTENSEN, Jeppe, Kejser , DYHRING, Tino
IPC分类号： C07D471/08 , A61K31/55 , A61P25/00
CPC分类号： C07D471/08
摘要： This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonane derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
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公开(公告)号：EP1819709B1
公开(公告)日：2009-02-11
申请号：EP05817438.4
申请日：2005-11-29
申请人： NEUROSEARCH A/S
发明人： PETERS, Dan , TIMMERMANN, Daniel, B. , OLSEN, Gunnar, M. , NIELSEN, Elsebet, Østergaard , JØRGENSEN, Tino, Dyhring
IPC分类号： C07D487/08 , A61K31/4995 , A61P25/00
CPC分类号： C07D487/08
摘要： This invention relates to novel diazabicyclic aryl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
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公开(公告)号：EP1987033A1
公开(公告)日：2008-11-05
申请号：EP07712214.1
申请日：2007-02-13
申请人： NEUROSEARCH A/S
发明人： PETERS, Dan , TIMMERMANN, Daniel, B. , OLSEN, Gunnar, M. , NIELSEN, Elsebet, Østergaard , CHRISTENSEN, Jeppe, Kejser , DYHRING, Tino
IPC分类号： C07D471/08 , A61K31/4995 , A61P25/28
CPC分类号： C07D471/08
摘要： This invention relates to novel diaza-bicyclo-alkane derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
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8.发明公开DIAZABICYCLIC ARYL DERIVATIVES AND THEIR USE AS CHINOLINERGIC LIGANDS AT THE NICOTINIC ACETYLCHOLINE RECEPTORS 有权二氮杂双环芳基衍生物和它们作为配位体CHINOLINERGISCHE烟碱乙酰胆碱受体使用
公开(公告)号：EP1863819A2
公开(公告)日：2007-12-12
申请号：EP06708216.4
申请日：2006-02-13
申请人： NEUROSEARCH A/S
发明人： PETERS, Dan , TIMMERMANN, Daniel, B. , OLSEN, Gunnar, M. , NIELSEN, Elsebet, Østergaard , DYHRING, Tino
IPC分类号： C07D487/08 , C07D471/08 , A61K31/551 , A61P25/28
CPC分类号： C07D471/08 , C07D487/08
摘要： This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
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9.发明公开NOVEL 9-AZA-BICYCLO¬3.3.1|NONANE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS 审中-公开新型9-氮杂双环[3.3.1] NONANDERIVE及其作为单胺类神经递质再摄取抑制剂
公开(公告)号：EP1761527A1
公开(公告)日：2007-03-14
申请号：EP05756925.3
申请日：2005-06-14
申请人： NEUROSEARCH A/S
IPC分类号： C07D451/14 , A61K31/439 , A61P23/00
CPC分类号： C07D451/14
摘要： This invention relates to novel 9-aza-bicyclo[3.3.1]nonane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
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10.发明公开CHROMEN-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS 有权色烯-2-酮衍生物及其作为抑制剂MONOAMINNEUTROTRANSMITTERWIEDERAUFNAHME使用
公开(公告)号：EP2430020A1
公开(公告)日：2012-03-21
申请号：EP10716360.2
申请日：2010-05-06
申请人： NeuroSearch A/S
IPC分类号： C07D451/06 , A61K31/46
CPC分类号： C07D451/06 , A61K31/46
摘要： The present applications discloses novel 8-aza-bicyclo[3.2.1]oct-3-yloxy)- chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors. In other aspects the applications discloses the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
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