发明公开
EP1864678A1 Pigment epithelium-derived factor: characterization, genomic organization and sequence of the PEDF gene
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Von Pigmentepithel Stammender Faktor zur Hemmug der Glialzellen-Proliferation
- 专利标题： Pigment epithelium-derived factor: characterization, genomic organization and sequence of the PEDF gene
- 专利标题（中）： Von Pigmentepithel Stammender Faktor zur Hemmug der Glialzellen-Proliferation
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申请号： EP07007638.5申请日： 1995-06-06
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公开(公告)号： EP1864678A1公开(公告)日： 2007-12-12
- 发明人: Chader, Gerald J. , Becerra, Sofia Patricia , Schwartz, Joan P. , Taniwaki, Takayuki
- 申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- 申请人地址： The National Institute of Health, Office of Technology Transfer, 6011 Executive Boulevard, Suite 325 Rockville, MD 20852 US
- 专利权人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- 当前专利权人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- 当前专利权人地址： The National Institute of Health, Office of Technology Transfer, 6011 Executive Boulevard, Suite 325 Rockville, MD 20852 US
- 代理机构： Vossius & Partner
- 优先权： US257963 19940607; US367841 19941230
- 主分类号： A61K38/57
- IPC分类号： A61K38/57 ; C07K16/38 ; G01N33/53 ; C07K14/81
摘要：
Nucleic acids encoding the neurotrophic protein known as pigment epithelium-derived factor (PEDF), a truncated version of PEDF referred to as rPEDF, and equivalent proteins, vectors comprising such nucleic acids, host cells into which such vectors have been introduced, recombinant methods for producing PEDF, rPEDF, and equivalent proteins, the rPEDF protein and equivalent proteins of rPEDF and PEDF -BP, -BX and BA, and the PEDF protein produced by recombinant methods. Effects and use of these variants on: 1) neuronal differentiation (neurotrophic effect), 2) neuron survival (neuronotrophic effect), and 3) glial inhibition (gliastatic effect) are described.
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