公开(公告)号：EP1864678A1

公开(公告)日：2007-12-12

申请号：EP07007638.5

申请日：1995-06-06

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： Chader, Gerald J. ,  Becerra, Sofia Patricia ,  Schwartz, Joan P. ,  Taniwaki, Takayuki

IPC分类号： A61K38/57 ,  C07K16/38 ,  G01N33/53 ,  C07K14/81

CPC分类号： C07K14/811 ,  A61K38/00 ,  C07K14/475 ,  C07K16/38

摘要： Nucleic acids encoding the neurotrophic protein known as pigment epithelium-derived factor (PEDF), a truncated version of PEDF referred to as rPEDF, and equivalent proteins, vectors comprising such nucleic acids, host cells into which such vectors have been introduced, recombinant methods for producing PEDF, rPEDF, and equivalent proteins, the rPEDF protein and equivalent proteins of rPEDF and PEDF -BP, -BX and BA, and the PEDF protein produced by recombinant methods. Effects and use of these variants on: 1) neuronal differentiation (neurotrophic effect), 2) neuron survival (neuronotrophic effect), and 3) glial inhibition (gliastatic effect) are described.

摘要翻译： 编码称为色素上皮衍生因子（PEDF）的神经营养蛋白的核酸，被称为rPEDF的PEDF的截短形式，以及等效蛋白质，包含这种核酸的载体，其中引入了这样的载体的宿主细胞，重组方法 产生PEDF，rPEDF和相应的蛋白质，rPEDF蛋白和rPEDF和PEDF-BP，-BX和BA的相应蛋白质和通过重组方法产生的PEDF蛋白。 这些变体的作用和用途如下：1）神经元分化（神经营养作用），2）神经元存活（神经营养作用）和3）胶质细胞抑制（神经影响作用）。

公开(公告)号：EP1864678B1

公开(公告)日：2009-12-09

申请号：EP07007638.5

申请日：1995-06-06

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： Chader, Gerald J. ,  Becerra, Sofia Patricia ,  Schwartz, Joan P. ,  Taniwaki, Takayuki

IPC分类号： A61K38/57 ,  C07K16/38 ,  G01N33/53 ,  C07K14/81

CPC分类号： C07K14/811 ,  A61K38/00 ,  C07K14/475 ,  C07K16/38