发明公开
- 专利标题： 2-AMINOQUINAZOLINE DERIVATIVES
- 专利标题（中）： 2- AMINOCHINAZOLINDERIVATE
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申请号： EP06745859.6申请日： 2006-04-28
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公开(公告)号： EP1878727A1公开(公告)日： 2008-01-16
- 发明人: KISHIKAWA, Kuniyuki , IMASE, Hidetomo , KASHIMA, Hajime , MORI, Kiyotoshi , IKEMURA, Toshihide , NAKASATO, Yoshisuke , TOMURO, Misato
- 申请人： KYOWA HAKKO KOGYO CO., LTD.
- 申请人地址： 6-1, Ohtemachi 1-chome Chiyoda-ku, Tokyo 100-8185 JP
- 专利权人： KYOWA HAKKO KOGYO CO., LTD.
- 当前专利权人： KYOWA HAKKO KOGYO CO., LTD.
- 当前专利权人地址： 6-1, Ohtemachi 1-chome Chiyoda-ku, Tokyo 100-8185 JP
- 代理机构： Vossius & Partner
- 优先权： JP2005130704 20050428
- 国际公布： WO2006118256 20061109
- 主分类号： C07D239/84
- IPC分类号： C07D239/84 ; A61K31/517 ; A61K31/519 ; A61K31/5377 ; A61P1/04 ; A61P1/18 ; A61P3/10 ; A61P7/00 ; A61P7/02 ; A61P9/00 ; A61P9/10 ; A61P11/00 ; A61P13/12 ; A61P17/00 ; A61P17/06 ; A61P19/02 ; A61P19/06 ; A61P19/10 ; A61P25/00 ; A61P25/28 ; A61P29/00
摘要：
The present invention provides 2-aminoquinazoline derivatives represented by formula (I):
wherein R 1 and R 2 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, and the like;
X represents a bond or CR 7a R 7b wherein R 7a and R 7b may be the same or different and each represents a hydrogen atom, and the like;
when X is a bond, R 3 represents substituted or unsubstituted aryl or a substituted or unsubstituted aromatic heterocyclic group;
when X is CR 7a R 7b wherein R 7a and R 7b have the same meanings as defined above, respectively, R 3 represents substituted or unsubstituted lower alkoxy, substituted or unsubstituted aryl, and the like;
R 4 represents a hydrogen atom, hydroxy, substituted or unsubstituted lower alkoxy, and the like; and
R 5 represents a hydrogen atom, substituted or unsubstituted aryl, and the like, or a pharmaceutically acceptable salt thereof.
wherein R 1 and R 2 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, and the like;
X represents a bond or CR 7a R 7b wherein R 7a and R 7b may be the same or different and each represents a hydrogen atom, and the like;
when X is a bond, R 3 represents substituted or unsubstituted aryl or a substituted or unsubstituted aromatic heterocyclic group;
when X is CR 7a R 7b wherein R 7a and R 7b have the same meanings as defined above, respectively, R 3 represents substituted or unsubstituted lower alkoxy, substituted or unsubstituted aryl, and the like;
R 4 represents a hydrogen atom, hydroxy, substituted or unsubstituted lower alkoxy, and the like; and
R 5 represents a hydrogen atom, substituted or unsubstituted aryl, and the like, or a pharmaceutically acceptable salt thereof.
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