公开(公告)号：EP1878727A1

公开(公告)日：2008-01-16

申请号：EP06745859.6

申请日：2006-04-28

申请人： KYOWA HAKKO KOGYO CO., LTD.

发明人： KISHIKAWA, Kuniyuki ,  IMASE, Hidetomo ,  KASHIMA, Hajime ,  MORI, Kiyotoshi ,  IKEMURA, Toshihide ,  NAKASATO, Yoshisuke ,  TOMURO, Misato

IPC分类号： C07D239/84 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5377 ,  A61P1/04 ,  A61P1/18 ,  A61P3/10 ,  A61P7/00 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P13/12 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P19/06 ,  A61P19/10 ,  A61P25/00 ,  A61P25/28 ,  A61P29/00

CPC分类号： C07D405/12 ,  C07D239/84 ,  C07D401/12 ,  C07D403/12 ,  C07D405/04

摘要： The present invention provides 2-aminoquinazoline derivatives represented by formula (I):

wherein R 1 and R 2 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, and the like;
X represents a bond or CR 7a R 7b wherein R 7a and R 7b may be the same or different and each represents a hydrogen atom, and the like;
when X is a bond, R 3 represents substituted or unsubstituted aryl or a substituted or unsubstituted aromatic heterocyclic group;
when X is CR 7a R 7b wherein R 7a and R 7b have the same meanings as defined above, respectively, R 3 represents substituted or unsubstituted lower alkoxy, substituted or unsubstituted aryl, and the like;
R 4 represents a hydrogen atom, hydroxy, substituted or unsubstituted lower alkoxy, and the like; and
R 5 represents a hydrogen atom, substituted or unsubstituted aryl, and the like, or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明提供由式（I）表示的2-氨基喹唑啉衍生物：其中R 1和R 2可以相同或不同，各自表示氢原子，取代或未取代的低级烷基等; X表示键或CR 7a R 7b，其中R 7a和R 7b可以相同或不同，各自表示氢原子等; 当X为键时，R 3为取代或未取代的芳基或取代或未取代的芳族杂环基; 当X为CR 7a R 7b，其中R 7a和R 7b分别具有与上述相同的含义时，R 3表示取代或未取代的低级烷氧基，取代或未取代的芳基等; R 4表示氢原子，羟基，取代或未取代的低级烷氧基等; R 5表示氢原子，取代或未取代的芳基等，或其药学上可接受的盐。