发明公开
EP1899371A2 METHOD FOR PREPARING A COVALENTLY CROSS LINKED OLIGOMER OF AMYLOID BETA PEPTIDES
审中-公开
用于生产由淀粉样蛋白β肽共价交联的低聚物
- 专利标题： METHOD FOR PREPARING A COVALENTLY CROSS LINKED OLIGOMER OF AMYLOID BETA PEPTIDES
- 专利标题（中）： 用于生产由淀粉样蛋白β肽共价交联的低聚物
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申请号： EP06785554.4申请日： 2006-06-26
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公开(公告)号： EP1899371A2公开(公告)日： 2008-03-19
- 发明人: GRIMM, Karen, M. , JOYCE, Joseph, G , LIANG, Xiaoping , NAWROCKI, Denise
- 申请人： Merck & Co., Inc.
- 申请人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 代理机构： Buchan, Gavin MacNicol
- 优先权： US695528P 20050630
- 国际公布： WO2007005358 20070111
- 主分类号： C07K14/47
- IPC分类号： C07K14/47 ; A61K47/48 ; A61K39/095 ; A61K39/385
摘要：
The invention relates to a method for the preparation of a stabilized cross-linked oligomer of amyloid beta using a near-zero length bifunctional cross-linking agent for use as an immunogen for the generation of antibodies for the treatment of Alzheimer’s Disease and other conditions related to abnormal amyloid beta aggregation. A preferred bifunctional cross-linking agent is 1,5-difluoro-2,4-dinitrobenzene (DFDNB).
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