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1.发明公开METHOD FOR PREPARING A COVALENTLY CROSS LINKED OLIGOMER OF AMYLOID BETA PEPTIDES 审中-公开用于生产由淀粉样蛋白β肽共价交联的低聚物
公开(公告)号：EP1899371A2
公开(公告)日：2008-03-19
申请号：EP06785554.4
申请日：2006-06-26
申请人： Merck & Co., Inc.
IPC分类号： C07K14/47 , A61K47/48 , A61K39/095 , A61K39/385
CPC分类号： A61K39/0007 , A61K47/646 , A61K2039/6068 , A61K2039/627
摘要： The invention relates to a method for the preparation of a stabilized cross-linked oligomer of amyloid beta using a near-zero length bifunctional cross-linking agent for use as an immunogen for the generation of antibodies for the treatment of Alzheimer’s Disease and other conditions related to abnormal amyloid beta aggregation. A preferred bifunctional cross-linking agent is 1,5-difluoro-2,4-dinitrobenzene (DFDNB).
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公开(公告)号：EP1455817B1
公开(公告)日：2008-12-31
申请号：EP02790044.8
申请日：2002-12-06
申请人： Merck & Co., Inc.
发明人： JOYCE, Joseph, G , COOK, James, C. III , ABEYGUNAWARDANA, Chitrananda , GRIMM, Karen, M. , PRZYSIECKI, Craig, T. , HEPLER, Robert, W. , IP, Charlotte, C. , ROPER, Keith , XU, Qinwei , JANSEN, Kathrin, U. , KELLER, Paul, M. , COPE, Leslie, D.
IPC分类号： A61K39/02 , A61K39/085 , C08B37/00
CPC分类号： A61K39/085
摘要： A high molecular weight polysaccharide intracellular adhesin (SAE) antigen having the general structure of poly- 1,6,β-2-amidoglucopyranoside, which is variable substituted with N-acetyl and O-succinyl substituents is described. Also, a method is given for isolating this antigen from Staphylococcus aureus. The SAE can be used in a vaccine, either alone, conjugated to an immunogenic protein, and/or with an immunogenic adjuvant.
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公开(公告)号：EP1455817A2
公开(公告)日：2004-09-15
申请号：EP02790044.8
申请日：2002-12-06
申请人： Merck & Co., Inc.
发明人： JOYCE, Joseph, G , COOK, James, C. III , ABEYGUNAWARDANA, Chitrananda , GRIMM, Karen, M. , PRZYSIECKI, Craig, T. , HEPLER, Robert, W. , IP, Charlotte, C. , ROPER, Keith , XU, Qinwei , JANSEN, Kathrin, U. , KELLER, Paul, M. , COPE, Leslie, D.
IPC分类号： A61K39/02 , A61K39/085 , C08B37/00
CPC分类号： A61K39/085
摘要： A high molecular weight polysaccharide intracellular adhesin (SAE) antigen having the general structure of poly- 1,6,β-2-amidoglucopyranoside, which is variable substituted with N-acetyl and O-succinyl substituents is described. Also, a method is given for isolating this antigen from Staphylococcus aureus. The SAE can be used in a vaccine, either alone, conjugated to an immunogenic protein, and/or with an immunogenic adjuvant.
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