发明公开
EP1901745A2 SYNERGISTIC MODULATION OF FLT3 KINASE USING AMINOPYRIMIDINES KINASE MODULATORS AND A FARNESYL TRANSFERASE INHIBITOR
审中-公开
FLT3激酶MT氨基嘧啶激酶调节剂的协同调制和法尼基转移酶抑制剂
- 专利标题： SYNERGISTIC MODULATION OF FLT3 KINASE USING AMINOPYRIMIDINES KINASE MODULATORS AND A FARNESYL TRANSFERASE INHIBITOR
- 专利标题（中）： FLT3激酶MT氨基嘧啶激酶调节剂的协同调制和法尼基转移酶抑制剂
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申请号： EP06772631.5申请日： 2006-06-07
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公开(公告)号： EP1901745A2公开(公告)日： 2008-03-26
- 发明人: BAUMANN, Christian, Andrew , GAUL, Michael, David
- 申请人： Janssen Pharmaceutica NV
- 申请人地址： Turnhoutseweg 30 2340 Beerse BE
- 专利权人： Janssen Pharmaceutica NV
- 当前专利权人： Janssen Pharmaceutica NV
- 当前专利权人地址： Turnhoutseweg 30 2340 Beerse BE
- 代理机构： Warner, James Alexander
- 优先权： US689718P 20050610
- 国际公布： WO2006135713 20061221
- 主分类号： A61K31/4709
- IPC分类号： A61K31/4709
摘要：
The invention is directed to a method of inhibiting FLT3 tyrosine kinase activity or expression or reducing FLT3 kinase activity or expression in a cell or a subject comprising the administration of a farnesyl transferase inhibitor and a FLT3 kinase inhibitor selected from aminopyrimidine compounds of Formula I': where R3, B, Z, r and R1 are as defined herein. Included within the present invention is both prophylactic and therapeutic methods for treating a subject at risk of (or susceptible to) developing a cell proliferative disorder or a disorder related to FLT3.
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