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公开(公告)号：EP1899319A2
公开(公告)日：2008-03-19
申请号：EP06772478.1
申请日：2006-06-07
发明人： BAINDUR, Nand , GAUL, Michael, David , KREUTTER, Kevin, Douglas , BAUMANN, Christian, Andrew , XU, Guozhang , KIM, Alexander, J. , ZHAO, Bao-Ping
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04
摘要： The invention is directed to aminoquinoline and aminoquinazoline compounds of Formula I: where R1, R2, R3, B, Z, Q, p, q and X are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of FLT3 and/or TrkB, the use of such compounds to reduce or inhibit kinase activity of FLT3 and/or TrkB in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to FLT3 and/or TrkB. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.
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2.发明公开SYNERGISTIC MODULATION OF FLT3 KINASE USING AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS 审中-公开与喹啉和喹唑啉激酶调节FLT3激酶协同调制
公开(公告)号：EP1893206A2
公开(公告)日：2008-03-05
申请号：EP06772443.5
申请日：2006-06-07
IPC分类号： A61K31/4709 , A61K31/517 , A61P35/00
CPC分类号： A61K31/4709 , A61K31/517 , A61K45/06 , A61K2300/00
摘要： The invention is directed to a method of inhibiting FLT3 tyrosine kinase activity or expression or reducing FLT3 kinase activity or expression in a cell or a subject comprising the administration of a farnesyl transferase inhibitor and a FLT3 kinase inhibitor selected from aminoquinoline and aminoquinazoline compounds of Formula (I’) : where R1, R2, R3, B, Z, Q, p, q and X are as defined herein. Included within the present invention is both prophylactic and therapeutic methods for treating a subject at risk of (or susceptible to) developing a cell proliferative disorder or a disorder related to FLT3.
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3.发明公开SYNERGISTIC MODULATION OF FLT3 KINASE USING AMINOPYRIMIDINES KINASE MODULATORS AND A FARNESYL TRANSFERASE INHIBITOR 审中-公开FLT3激酶MT氨基嘧啶激酶调节剂的协同调制和法尼基转移酶抑制剂
公开(公告)号：EP1901745A2
公开(公告)日：2008-03-26
申请号：EP06772631.5
申请日：2006-06-07
IPC分类号： A61K31/4709
CPC分类号： A61K31/4709 , A61K9/0019 , A61K9/2018 , A61K31/506 , A61K45/06 , A61K2300/00
摘要： The invention is directed to a method of inhibiting FLT3 tyrosine kinase activity or expression or reducing FLT3 kinase activity or expression in a cell or a subject comprising the administration of a farnesyl transferase inhibitor and a FLT3 kinase inhibitor selected from aminopyrimidine compounds of Formula I': where R3, B, Z, r and R1 are as defined herein. Included within the present invention is both prophylactic and therapeutic methods for treating a subject at risk of (or susceptible to) developing a cell proliferative disorder or a disorder related to FLT3.
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4.发明公开INTERMEDIATES USEFUL IN THE SYNTHESIS OF ALKYLQUINOLINE AND ALKYLQUINAZOLINE KINASE MODULATORS AND RELATED METHODS OF SYNTHESIS 审中-公开ALKYLCHINOLIN-和合成的合适ALKYLCHINAZOLINKINASEMODULATOREN产品及任何相关合成过程之间
公开(公告)号：EP1891040A1
公开(公告)日：2008-02-27
申请号：EP06760725.9
申请日：2006-06-07
IPC分类号： C07D401/04 , C07D401/14 , C07D413/14 , C07D405/14
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14
摘要： The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula C: wherein R1, R2, R99, and X are as defined herein, the use of such compounds in the sysnthesis of protein tyrosine kinase inhibitors, particularly inhibitors of FLT3 and/or c-kit and/or TrkB.
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