发明公开
- 专利标题： FUSED TRICYCLIC (MGLUR1) ANTAGONISTS AS THERAPEUTIC AGENTS
- 专利标题（中）： 稠合三环（mGluR1）拮抗剂治疗剂
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申请号： EP06801600.5申请日： 2006-10-16
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公开(公告)号： EP1928885A1公开(公告)日： 2008-06-11
- 发明人: BENNETT, Chad, E. , GREENLEE, William, J. , KNUTSON, Chad, E. , BURNETT, Duane, A.
- 申请人： Schering Corporation
- 申请人地址： 2000 Galloping Hill Road Kenilworth, NJ 07033-0530 US
- 专利权人： Schering Corporation
- 当前专利权人： Schering Corporation
- 当前专利权人地址： 2000 Galloping Hill Road Kenilworth, NJ 07033-0530 US
- 代理机构： Adams, Harvey Vaughan John
- 优先权： US709562P 20050819
- 国际公布： WO2007032854 20070322
- 主分类号： C07D495/14
- IPC分类号： C07D495/14 ; A61P25/00 ; A61P13/00 ; A61P25/06 ; A61P25/22 ; A61P25/04
摘要：
In its many embodiments, the present invention provides tricyclic compounds of formula (I) (wherein J1-J3, X, Z, and R1, R3, and R4 are as defined herein) useful as metabotropic glutamate receptor (mGluR) antagonists, particularly as selective metabotropic glutamate receptor 1 antagonists, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds and compositions to treat diseases associated with metabotropic glutamate receptor (e.g., mGluR1) such as, for example, pain, migraine, anxiety, urinary incontinence and neurodegenerative diseases such Alzheimer's disease.
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