发明公开
EP1931645A2 N- (3-AMINO-QUINOXALIN-2-YL) -SULFONAMIDE DERIVATIVES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS
有权
N-（3-氨基 - 喹喔啉-2-基）磺酰胺衍生物及其作为磷脂酰肌醇-3-激酶抑制剂使用
- 专利标题： N- (3-AMINO-QUINOXALIN-2-YL) -SULFONAMIDE DERIVATIVES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS
- 专利标题（中）： N-（3-氨基 - 喹喔啉-2-基）磺酰胺衍生物及其作为磷脂酰肌醇-3-激酶抑制剂使用
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申请号： EP06836252.4申请日： 2006-10-09
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公开(公告)号： EP1931645A2公开(公告)日： 2008-06-18
- 发明人: BAJJALIEH, William , CANNE BANNEN, Lynne , BROWN, S., David , KEARNEY, Patrick , MAC, Morrison, B. , MARLOWE, Charles, K. , NUSS, John, M. , TESFAI, Zerom , WANG, Yong , XU, Wei
- 申请人： Exelixis, Inc.
- 申请人地址： 210 East Grand Avenue P.O. Box 511 South San Francisco, CA 94083-0511 US
- 专利权人： Exelixis, Inc.
- 当前专利权人： Exelixis, Inc.
- 当前专利权人地址： 210 East Grand Avenue P.O. Box 511 South San Francisco, CA 94083-0511 US
- 代理机构： Main, Malcolm Charles
- 优先权： US724570P 20051007; US812690P 20060608
- 国际公布： WO2007044729 20070419
- 主分类号： C07D241/44
- IPC分类号： C07D241/44 ; C07D401/12 ; C07D403/12 ; C07D407/12 ; C07D409/12 ; C07D413/12 ; C07D417/12 ; A61K31/498 ; A61K31/4985 ; A61P35/00
摘要：
The present invention comprises small molecule inhibitors of phosphatidylinositol 3-kinase (PI3K), which is associated with a number of malignancies such as ovarian cancer, cervical cancer, breast cancer, colon cancer, rectal cancer, and glioblastomas, among others. Accordingly, the compounds of the present invention are useful for treating, preventing, and/or inhibiting these diseases.
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