发明公开
EP1934606A2 OPTIMIZED TRPM8 NUCLEIC ACID SEQUENCES AND THEIR USE IN CELL BASED ASSAYS AND TEST KITS TO IDENTIFY TRPM8 MODULATORS
审中-公开
优化TRPM8 NUCLEIC序列及它们在基于细胞的试验和检测试剂盒用于识别TRPM8调节剂
- 专利标题： OPTIMIZED TRPM8 NUCLEIC ACID SEQUENCES AND THEIR USE IN CELL BASED ASSAYS AND TEST KITS TO IDENTIFY TRPM8 MODULATORS
- 专利标题（中）： 优化TRPM8 NUCLEIC序列及它们在基于细胞的试验和检测试剂盒用于识别TRPM8调节剂
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申请号： EP06816320.3申请日： 2006-10-04
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公开(公告)号： EP1934606A2公开(公告)日： 2008-06-25
- 发明人: SERVANT, Guy , BRUST, Paul , MOYER, Bryan , LU, Min , ECHEVERRI, Fernando , DAHAN, David , ZOLLER, Mark , WILLIAMS, Mark , KIMMICH, Rachel , KAMDAR, Poonit , DITSCHUN, Tanya , PATRON, Andrew
- 申请人： Senomyx, Inc.
- 申请人地址： 4767 Nexus Centre Drive San Diego, CA 92121 US
- 专利权人： Senomyx, Inc.
- 当前专利权人： Senomyx, Inc.
- 当前专利权人地址： 4767 Nexus Centre Drive San Diego, CA 92121 US
- 代理机构： Baldock, Sharon Claire
- 优先权： US724776P 20051011; US724777P 20051011; US536394 20060928
- 国际公布： WO2007047127 20070426
- 主分类号： G01N33/53
- IPC分类号： G01N33/53
摘要：
Modified human TRPM8 nucleic acid sequences which are efficiently expressed in human cells and cell-based assays and test kits containing same are provided. These assays identify TRPM8 modulators using cells that express a modified human TRPM8 nucleic acid sequence according to the invention, wherein said sequence has been modified relative to a wild-type human TRPM8 nucleic acid sequence in order to optimize ion channel expression in desired cells. Assays using these modified TRPM8 sequences have been shown to identify compounds that modulate the human TRPM8 ion channel better or comparably to known coolants such as menthol and icilin.
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