发明公开
- 专利标题： CHIMERIC OLIGOMERIC COMPOUNDS FOR MODULATION OF SPLICING
- 专利标题（中）： CHIMERE低聚物化合物调制剪接
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申请号： EP06802842.2申请日： 2006-08-29
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公开(公告)号： EP1937312A2公开(公告)日： 2008-07-02
- 发明人: BENNETT, C. Frank , DEAN, Nicholas, M. , KOLE, Ryszard , KOPCZYNSKI, Casey, C.
- 申请人： Isis Pharmaceuticals, Inc. , Ercole Biotech, Inc.
- 申请人地址： 1896 Rutherford Road Carlsbad, CA 92008 US
- 专利权人： Isis Pharmaceuticals, Inc.,Ercole Biotech, Inc.
- 当前专利权人： Isis Pharmaceuticals, Inc.,Ercole Biotech, Inc.
- 当前专利权人地址： 1896 Rutherford Road Carlsbad, CA 92008 US
- 代理机构： Hallybone, Huw George
- 优先权： US712674P 20050830
- 国际公布： WO2007028065 20070308
- 主分类号： A61K48/00
- IPC分类号： A61K48/00
摘要：
Disclosed herein are compounds, compositions and methods for modulating splicing of a selected target mRNA. Further provided are uses of the disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Methods of enhancing cellular uptake, modulating tissue distribution and enhancing pharmacological activity of RNase H-independent antisense oligonucleotides are also provided.
公开/授权文献
- EP1937312B1 CHIMERIC OLIGOMERIC COMPOUNDS FOR MODULATION OF SPLICING 公开/授权日：2016-06-29
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