发明公开
EP1942948A2 COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF NAV1.8 GENE
审中-公开
组合物和方法Nav1.8的基因的表达抑制
- 专利标题： COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF NAV1.8 GENE
- 专利标题（中）： 组合物和方法Nav1.8的基因的表达抑制
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申请号： EP06837005.5申请日： 2006-11-03
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公开(公告)号： EP1942948A2公开(公告)日： 2008-07-16
- 发明人: SAH, Dinah, Wen-Yee , FRANK-KAMENETSKY, Maria , GEICK, Anke , HADWIGER, Philipp , ROEHL, Ingo , TAN, Pamela , VORNLOCHER, Hans-Peter
- 申请人： Alnylam Pharmaceuticals Inc.
- 申请人地址： 300 Third Street Cambridge, MA 02142 US
- 专利权人： Alnylam Pharmaceuticals Inc.
- 当前专利权人： Alnylam Pharmaceuticals Inc.
- 当前专利权人地址： 300 Third Street Cambridge, MA 02142 US
- 代理机构： Ehnis, Tobias
- 优先权： US733816P 20051104; US741586P 20051202; US763202P 20060126; US795443P 20060427; US849364P 20061004
- 国际公布： WO2007056326 20070518
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C07J17/00 ; C07H21/02 ; C12N5/10 ; C12N5/08 ; C07F9/6533
摘要：
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Nav1.8 gene (Nav1.8 gene), comprising an antisense strand having a nucleotide sequence which is less that 25 nucleotides in length and which is substantially complementary to at least a part of the Nav1.8 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of the Nav1.8 gene using the pharmaceutical composition; and methods for inhibiting the expression of the Nav1.8 gene gene in a cell
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