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1.发明公开
公开(公告)号：EP1942948A2
公开(公告)日：2008-07-16
申请号：EP06837005.5
申请日：2006-11-03
发明人： SAH, Dinah, Wen-Yee , FRANK-KAMENETSKY, Maria , GEICK, Anke , HADWIGER, Philipp , ROEHL, Ingo , TAN, Pamela , VORNLOCHER, Hans-Peter
CPC分类号： C12N15/1138 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3515 , C12N2310/3521
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Nav1.8 gene (Nav1.8 gene), comprising an antisense strand having a nucleotide sequence which is less that 25 nucleotides in length and which is substantially complementary to at least a part of the Nav1.8 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of the Nav1.8 gene using the pharmaceutical composition; and methods for inhibiting the expression of the Nav1.8 gene gene in a cell
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公开(公告)号：EP1802644A2
公开(公告)日：2007-07-04
申请号：EP05802154.4
申请日：2005-09-26
CPC分类号： C12N15/113 , A61K31/7105 , A61K31/718 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3515 , C12N2310/3521
摘要： The invention relates to compositions and methods for modulating the expression of apolipoprotein B, and more particularly to the downregulation of apolipoprotein B by chemically modified oligonucleotides.
摘要翻译： 本发明涉及用于调节载脂蛋白B的表达的组合物和方法，并且更具体地涉及通过化学修饰的寡核苷酸下调载脂蛋白B.
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公开(公告)号：EP1824872B1
公开(公告)日：2012-02-08
申请号：EP05854523.7
申请日：2005-12-14
CPC分类号： C12N15/1135 , C12N2310/14
摘要： The invention relates to compositions and methods for modulating the expression of the MLL-AF4 fusion gene, and more particularly to the downregulation of MLL-AF4 by chemically modified oligonucleotides.
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公开(公告)号：EP1824872A2
公开(公告)日：2007-08-29
申请号：EP05854523.7
申请日：2005-12-14
IPC分类号： C07H21/04
CPC分类号： C12N15/1135 , C12N2310/14
摘要： The invention relates to compositions and methods for modulating the expression of the MLL-AF4 fusion gene, and more particularly to the downregulation of MLL-AF4 by chemically modified oligonucleotides.
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公开(公告)号：EP1802644B1
公开(公告)日：2012-11-07
申请号：EP05802154.4
申请日：2005-09-26
IPC分类号： C12N15/113 , C07H21/04 , A61K31/70 , C12N5/00
CPC分类号： C12N15/113 , A61K31/7105 , A61K31/718 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3515 , C12N2310/3521
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公开(公告)号：EP1896084A2
公开(公告)日：2008-03-12
申请号：EP06785707.8
申请日：2006-06-27
发明人： AKINC, Akin , DE FOUGEROLLES, Antonin , VORNLOCHER, Hans-Peter , HADWIGER, Philipp , BRAMLAGE, Birgit
IPC分类号： A61K48/00
CPC分类号： C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3521
摘要： The features of the present invention relate to compounds, compositions and methods useful for modulating the expression of HIF-1α, such as by the mechanism of RNA interference (RNAi). The compounds and compositions include iRNA agents that can be unmodified or chemically-modified.
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公开(公告)号：EP1941059A2
公开(公告)日：2008-07-09
申请号：EP06827135.2
申请日：2006-10-27
发明人： SAH, Dinah Wen-Yee , HADWIGER, Philipp , ROEHL, Ingo , BRAMLAGE, Birgit , TAN, Pamela , VORNLOCHER, Hans-Peter , BUMCROT, David
CPC分类号： C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3515 , C12N2310/3521
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Huntingtin gene (HD gene), comprising an antisense strand having a nucleotide sequence which is less that 25 nucleotides in length and which is substantially complementary to at least a part of the HD gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of the HD gene, or a mutant form thereof, using the pharmaceutical composition; and methods for inhibiting the expression of the huntingtin gene in a cell.
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公开(公告)号：EP1814597A2
公开(公告)日：2007-08-08
申请号：EP05857009.4
申请日：2005-11-23
IPC分类号： A61K48/00
CPC分类号： C12N15/1135 , C12N2310/14 , C12N2310/315 , C12N2310/32 , C12N2310/33
摘要： The invention relates to compositions and methods for modulating the expression of Bcr-Abl, and more particularly to the down-regulation of Bcr-Abl mRNA and Bcr-Abl protein levels by oligonucleotides via RNA interference, e.g., chemically modified oligonucleotides.
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公开(公告)号：EP1765847A2
公开(公告)日：2007-03-28
申请号：EP05780090.6
申请日：2005-05-27
发明人： VORNLOCHER, Hans-Peter , HADWIGER, Philipp , ZIMMERMANN, Tracy, Stage , MANOHARAN, Muthiah , RAJEEV, Kallanthottathil G. , ROEHL, Ingo , AKINC, Akin
CPC分类号： C07H21/02 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/323 , C12N2310/3231 , C12N2310/53 , C12N2320/51 , C12N2310/3521 , C12N2310/3525 , C12N2310/3527
摘要： This invention relates to modified double-stranded oligoribonucleic acid (dsRNA) having improved stability in cells and biological fluids, and methods of making and identifying dsRNA having improved stability, and of using the dsRNA to inhibit the expression or function of a target gene.
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