发明公开
EP1951704A1 1,3-DIHYDRO-BENZIMIDAZOL-2-YLIDENE AMINES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS REPLICATION
有权
用于治疗或预防病毒感染SUITABLE 1,3-二氢-2- YLIDENAMINE
- 专利标题: 1,3-DIHYDRO-BENZIMIDAZOL-2-YLIDENE AMINES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS REPLICATION
- 专利标题(中): 用于治疗或预防病毒感染SUITABLE 1,3-二氢-2- YLIDENAMINE
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申请号: EP06708798.1申请日: 2006-03-17
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公开(公告)号: EP1951704A1公开(公告)日: 2008-08-06
- 发明人: BONFANTI, Jean-François , FORTIN, Jérôme, Michel, Claude , DORANGE, Ismet
- 申请人: Tibotec Pharmaceuticals Ltd.
- 申请人地址: Eastgate Village Eastgate Little Island Co Cork IE
- 专利权人: Tibotec Pharmaceuticals Ltd.
- 当前专利权人: Tibotec Pharmaceuticals Ltd.
- 当前专利权人地址: Eastgate Village Eastgate Little Island Co Cork IE
- 代理机构: Wante, Dirk Paul Maria
- 优先权: EP05102127 20050317
- 国际公布: WO2006097534 20060921
- 主分类号: C07D401/06
- IPC分类号: C07D401/06 ; C07D401/14 ; A61K31/4184 ; A61P11/00
摘要:
Novel 1,3-dihydro-benzimidazo l-2-ylidene amine derivatives of formula (I) the addition salts and stereochemically iso meric forms wherein each Alk is C1-6alkanediyl; Q is hydrogen; C1-6alkyl subst ituted with one or two Ar2 radicals; C1-66alkyl subst ituted with quinolinyl, oxazolidinyl, thiazolidinyl, morpholinyl, thiomorpholinyl, or with pyrrolidinonyl; -CO-Ar2; or Q is a radical of formula wherein t is 1, 2 or 3; R4 is amino, mono-or di(C1-6alkyl)amino ; R1 is Ar2, -CO-Ar2 or a monocyclic or bicyclic heterocycle which may optionally be subst ituted; R2 is as R1 and additionally can be hydrogen; where Q is other than hydrogen, R3 is hydrogen; and where Q is other than hydrogen, R3 is a radical: (b) wherein R6 is hydrogen, C1-6alkyl, substituted C1-6alkyl; R7, R8, R9 are halo, cyano, C1-6alkyl, substituted C1-6alkyl, C2-6alkenyl, cyanoC2-6alkenyl, C2-6alkynyl, cyanoC2 6alkynyl, Ar11, R10a-O-, R10a-S-, -N(R5aR5b), R10a-O-C(=O)-, N(R5aR5b)-C(=O)-, R10a-C(=O)-NR5b-, R10b-C(=O)-O-; and R8 and/or R9 may also be hydrogen; which are RSV inhibitors. Compositions containing these compounds and processes for preparing these compounds and compositions.
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