发明公开
EP1954305A2 RECOMBINANT PLASMODIUM FALCIPARUM MEROZOITE SURFACE PROTEINS 4 AND 5 AND THEIR USE 有权
重组恶性疟原虫裂殖子表面蛋白4和5及其用途

  • 专利标题: RECOMBINANT PLASMODIUM FALCIPARUM MEROZOITE SURFACE PROTEINS 4 AND 5 AND THEIR USE
  • 专利标题(中): 重组恶性疟原虫裂殖子表面蛋白4和5及其用途
  • 申请号: EP06842385.4
    申请日: 2006-11-23
  • 公开(公告)号: EP1954305A2
    公开(公告)日: 2008-08-13
  • 发明人: LONGACRE, ShirleyPOLSON, HannahPERRAUT, RonaldNATO, Farida
  • 申请人: INSTITUT PASTEUR
  • 申请人地址: 25-28, rue du Docteur Roux 75724 Paris Cédex 15 FR
  • 专利权人: INSTITUT PASTEUR
  • 当前专利权人: INSTITUT PASTEUR
  • 当前专利权人地址: 25-28, rue du Docteur Roux 75724 Paris Cédex 15 FR
  • 代理机构: Desaix, Anne
  • 优先权: US739973P 20051123
  • 国际公布: WO2007060550 20070531
  • 主分类号: A61K39/015
  • IPC分类号: A61K39/015
RECOMBINANT PLASMODIUM FALCIPARUM MEROZOITE SURFACE PROTEINS 4 AND 5 AND THEIR USE
摘要:
The invention provides constructs in which the nucleic acids encoding Plasmodium falciparum MSP4 and MSP5, and the resulting polypeptides, have been modified. More particularly, this invention provides constructs encoding recombinant MSP4 and MSP5 polypeptides, which are expressed as soluble, secreted polypeptides in a baculovirus-insect cell expression system. It was surprisingly found that the recombinant polypeptides contain an EGF-like domain at the C-terminus that is properly folded in the polypeptide.
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