发明公开
EP1960368A1 2,4,5-TRIPHENYL IMIDAZOLINE DERIVATIVES AS INHIBITORS OF THE INTERACTION BETWEEN P53 AND MDM2 PROTEINS FOR USE AS ANTICANCER AGENTS
有权
2,4,5- TRIPHENYLIMIDAZOLINDERIVATE之间。如P53和MDM2蛋白的相互作用以用作抗癌剂抑制剂
- 专利标题: 2,4,5-TRIPHENYL IMIDAZOLINE DERIVATIVES AS INHIBITORS OF THE INTERACTION BETWEEN P53 AND MDM2 PROTEINS FOR USE AS ANTICANCER AGENTS
- 专利标题(中): 2,4,5- TRIPHENYLIMIDAZOLINDERIVATE之间。如P53和MDM2蛋白的相互作用以用作抗癌剂抑制剂
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申请号: EP06819663.3申请日: 2006-11-22
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公开(公告)号: EP1960368A1公开(公告)日: 2008-08-27
- 发明人: DING, Qingjie , GRAVES, Bradford James , KONG, Norman , LIU, Jin-Jun , LOVEY, Allen John , PIZZOLATO, Giacomo , ROBERTS, John Lawson , SO, Sung-Sau , VU, Binh Thanh , WOVKULICH, Peter Michael
- 申请人: F. Hoffmann-La Roche AG
- 申请人地址: Grenzacherstrasse 124 4070 Basel CH
- 专利权人: F. Hoffmann-La Roche AG
- 当前专利权人: F. Hoffmann-La Roche AG
- 当前专利权人地址: Grenzacherstrasse 124 4070 Basel CH
- 代理机构: Klein, Thomas
- 优先权: US741223P 20051201; US852747P 20061019
- 国际公布: WO2007063013 20070607
- 主分类号: C07D233/22
- IPC分类号: C07D233/22 ; C07D233/26 ; C07D401/06 ; C07D403/06 ; C07D407/12 ; C07D409/12 ; C07D471/04 ; C07D487/04 ; A61K31/4164 ; A61K31/496 ; A61P35/00
摘要:
There is provided a compound of formula (I) and the pharmaceutically acceptable salts and esters thereof wherein X1 , X2, R1 , R2, R3, R4, R5 and R6 are herein described. The compounds exhibit activity as anticancer agents.
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