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公开(公告)号：EP3080097B1
公开(公告)日：2018-04-18
申请号：EP14809642.3
申请日：2014-12-10
IPC分类号： C07D401/14 , C07D403/06 , C07D403/14 , C07D409/14 , A61K31/4155 , A61K31/4439 , A61P29/00 , A61P11/06
CPC分类号： C07D403/06 , C07D401/14 , C07D403/14 , C07D409/14
摘要： This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are useful for the treatment of oncological, auto-immune, and inflammatory diseases caused by aberrant B-cell activation. Also disclosed are compositions containing compounds of Formula (I) and at least one carrier, diluent or excipient.
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2.发明公开NAPHTHYRIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE 有权NAPHTHYRIDINONDERIVATE和它们在治疗，减轻或预防疾病病毒的
公开(公告)号：EP2945945A1
公开(公告)日：2015-11-25
申请号：EP14703780.8
申请日：2014-01-07
发明人： WOLKERSTORFER, Andrea , SZOLAR, Oliver , HANDLER, Norbert , BUSCHMANN, Helmut , CUSACK, Stephen , SMITH, Mark , SO, Sung-Sau , HAWLEY, Ronald Charles , SIDDURI, Achyutharao
IPC分类号： C07D471/04 , A61K31/4375 , A61P31/12
CPC分类号： A61K31/519 , A61K31/4375 , A61K31/4985 , A61K31/513 , A61K45/06 , C07D401/04 , C07D471/02 , C07D471/04
摘要： The present invention relates to a compound having the general formula (V), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.
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公开(公告)号：EP2346819A1
公开(公告)日：2011-07-27
申请号：EP09751894.8
申请日：2009-11-09
发明人： CHEN, Li , FIROOZNIA, Fariborz , GILLESPIE, Paul , HE, Yun , LIN, Tai-An , MERTZ, Eric , SO, Sung-Sau , YUN, HongYing , ZHANG, Zhenshan
IPC分类号： C07C317/14 , C07C317/22 , C07C317/36 , C07D213/71 , C07D295/26 , A61K31/435 , A61K31/185 , A61P11/06 , A61P17/00 , A61P37/00 , A61P11/00
CPC分类号： C07D213/71 , C07C255/54 , C07C311/29 , C07C317/22 , C07C317/36 , C07C317/44 , C07C317/46 , C07C323/65 , C07C2601/02 , C07C2601/08 , C07D211/38 , C07D295/26 , C07D491/10
摘要： The invention is concerned with the compounds of formula I, and pharmaceutically acceptable salts and esters thereof, wherein W, X, Y, and R
1 - R
7 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐和酯，其中W，X，Y和R 1 -R 7在详细描述和权利要求书中定义。 另外，本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。 式I化合物是CRTH2受体的拮抗剂或部分激动剂，并可用于治疗与该受体相关的疾病和病症如哮喘。
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公开(公告)号：EP1919878B1
公开(公告)日：2010-09-08
申请号：EP06792493.6
申请日：2006-07-11
发明人： HAYNES, Nancy-Ellen , KERTESZ, Denis John , PIETRANICO-COLE, Sherrie Lynn , QIAN, Yimin , SCOTT, Nathan Robert , SO, Sung-Sau , THAKKAR, Kshitij Chhabilbhai , TILLEY, Jefferson Wright
IPC分类号： C07D237/14 , C07D237/16 , C07D237/18 , C07D403/10 , C07D403/12 , A61K31/501 , A61P5/16
CPC分类号： C07D237/14 , C07D237/16 , C07D237/18 , C07D403/10 , C07D403/12
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as obesity, hyperlipidemia, hypercholesterolemia and diabetes and other related disorders and diseases, and may be useful for other diseases such as NASH, atherosclerosis, cardiovascular diseases, hypothyroidism, thyroid cancer and other disorders and diseases related thereto.
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公开(公告)号：EP1560829B1
公开(公告)日：2008-02-20
申请号：EP03758072.7
申请日：2003-10-27
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04 , G01N2800/52
摘要： Disclosed are novel pyrimido compounds of the formula (I) wherein R1 to R9 are as defined in the specification, that are selective inhibitors of the Src family of tyrosine kinases. These compounds and their pharmaceutically acceptable salts are anti-proliferative agents useful in the treatment or control of solid tumors, in particular breast, colon, hepatic and pancreatic tumors. Also disclosed are pharmaceutical compositions containing these compounds and the use for treating cancer.
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公开(公告)号：EP3080099B1
公开(公告)日：2018-04-11
申请号：EP14809645.6
申请日：2014-12-10
IPC分类号： C07D401/14 , C07D403/06 , C07D403/14 , A61K31/4155 , A61K31/4439 , A61P29/00 , A61P11/06
CPC分类号： C07D403/06 , A61K31/4155 , A61K31/4439 , C07D401/14 , C07D403/14 , C07D487/04
摘要： This application discloses compounds according to generic Formula (I) wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are useful for the treatment of oncological, auto-immune, and inflammatory diseases caused by aberrant B-cell activation. Also disclosed are compositions containing compounds of Formula (I) and at least one carrier, diluent or excipient.
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公开(公告)号：EP3080098B1
公开(公告)日：2017-12-06
申请号：EP14809643.1
申请日：2014-12-10
IPC分类号： C07D401/14 , C07D403/06 , A61K31/4155 , A61K31/4439 , A61P29/00 , A61P11/06
CPC分类号： C07D403/06 , C07D401/14
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公开(公告)号：EP2321268A2
公开(公告)日：2011-05-18
申请号：EP09781520.3
申请日：2009-08-05
发明人： BLANC, Jean-Baptiste , CHEN, Li , FIROOZNIA, Fariborz , GILLESPIE, Paul , GOODNOW, Robert, Alan, Jr. , HE, Yun , LIN, Tai-An , SO, Sung-Sau , YUN, HongYing , ZHANG, Zhenshan
IPC分类号： C07C311/20 , C07C311/29 , C07C323/67 , C07D213/34 , C07D213/71 , A61P11/00 , A61K31/18 , A61K31/395
CPC分类号： C07D213/71 , C07C311/20 , C07C311/29 , C07C317/14 , C07C323/67 , C07C2602/10 , C07D213/34 , C07D409/04
摘要： The invention is concerned with the compounds of formula (I) and pharmaceutically acceptable salts and esters thereof, wherein R
1 -R
5 , A, B, Q, W, and X are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐和酯，其中R 1 -R 5，A，B，Q，W和X在具体实施方式和权利要求书中定义。 另外，本发明涉及制备和使用式（I）化合物的方法以及含有这些化合物的药物组合物。 式（I）化合物是CRTH2受体的拮抗剂，可用于治疗与该受体相关的疾病和病症如哮喘。
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公开(公告)号：EP2307382A1
公开(公告)日：2011-04-13
申请号：EP09780159.1
申请日：2009-07-06
发明人： CHEN, Li , FIROOZNIA, Fariborz , GILLESPIE, Paul , HE, Yun , LIN, Tai-An , SO, Sung-Sau , YUN, HongYing
IPC分类号： C07D231/56 , C07D401/12 , A61K31/416 , A61P37/00
CPC分类号： C07D231/56 , C07D401/12
摘要： The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Q, R1 -R3 and n are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
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公开(公告)号：EP1919878A1
公开(公告)日：2008-05-14
申请号：EP06792493.6
申请日：2006-07-11
发明人： HAYNES, Nancy-Ellen , KERTESZ, Denis John , PIETRANICO-COLE, Sherrie Lynn , QIAN, Yimin , SCOTT, Nathan Robert , SO, Sung-Sau , THAKKAR, Kshitij Chhabilbhai , TILLEY, Jefferson Wright
IPC分类号： C07D237/14 , C07D237/16 , C07D237/18 , C07D403/10 , C07D403/12 , A61K31/501 , A61P5/16
CPC分类号： C07D237/14 , C07D237/16 , C07D237/18 , C07D403/10 , C07D403/12
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as obesity, hyperlipidemia, hypercholesterolemia and diabetes and other related disorders and diseases, and may be useful for other diseases such as NASH, atherosclerosis, cardiovascular diseases, hypothyroidism, thyroid cancer and other disorders and diseases related thereto.
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