发明公开
EP1965785A1 COMPOUNDS WITH MEDICINAL EFFECTS DUE TO INTERACTION WITH THE GLUCOCORTICOID RECEPTOR
审中-公开
具有医疗效果LINKS由于与GLUCOCORTOID受体相互作用
- 专利标题： COMPOUNDS WITH MEDICINAL EFFECTS DUE TO INTERACTION WITH THE GLUCOCORTICOID RECEPTOR
- 专利标题（中）： 具有医疗效果LINKS由于与GLUCOCORTOID受体相互作用
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申请号： EP06841409.3申请日： 2006-12-18
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公开(公告)号： EP1965785A1公开(公告)日： 2008-09-10
- 发明人: HAMILTON, Niall Morton , GROVE, Simon James Anthony , KICZUN, Michael John , MORPHY, John, Richard , SHERBORNE, Brad , LITTLEWOOD, Peter Thomas Albert , BROWN, Angus Richard , KINGSBURY, Celia , OHLMEYER, Michael , HO, Koc-Kan , KULTGEN, Steven G.
- 申请人： N.V. Organon , Pharmacopeia Inc.
- 申请人地址： Kloosterstraat 6 5349 AB Oss NL
- 专利权人： N.V. Organon,Pharmacopeia Inc.
- 当前专利权人： N.V. Organon,Pharmacopeia Inc.
- 当前专利权人地址： Kloosterstraat 6 5349 AB Oss NL
- 代理机构： Broekkamp, Chris L. E.
- 优先权： US752526P 20051221
- 国际公布： WO2007071638 20070628
- 主分类号： A61K31/18
- IPC分类号： A61K31/18 ; A61K31/4439 ; C07C311/17 ; C07D401/12
摘要：
The invention provides for compounds having the structure according to the formula I wherein: X is a carbon or nitrogen atom; Ar is phenyl or heteroaromatic ring; R1 is hydrogen, halogen, CN or (1 C-4C)alkyl; R2 is hydrogen, halogen or optionally fluorinated (1 C-3C)alkoxy; R3 and R5 are independently hydrogen, optionally halogenated (1C- 4C)alkyl, optionally halogenated (1 C-4C)alkoxy, optionally halogenated aryl(1C-4C)alkoxy, optionally halogenated (1 C-4C)alkenyl or hydroxylmethyl; R4 is hydrogen, halogen, optionally halogenated (1 C-4C)alkoxy or optionally halogenated aryl(1 C-4C)alkoxy; R6 is hydrogen, benzyl, optionally substituted with one or more halogens or (1 C-4C)alkyl, or R6 is optionally halogenated (1 C-4C)alkyl; each R7 independently is hydrogen, halogen, optionally halogenated (1 C-4C)alkyl or optionally halogenated (1 C-4C)alkoxy and pharmaceutically suitable acid addition salts thereof for use as glucocorticoid receptor modulators, in particular for treatment of central nervous system disorders.
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