公开(公告)号：EP1965785A1

公开(公告)日：2008-09-10

申请号：EP06841409.3

申请日：2006-12-18

申请人： N.V. Organon ,  Pharmacopeia Inc.

发明人： HAMILTON, Niall Morton ,  GROVE, Simon James Anthony ,  KICZUN, Michael John ,  MORPHY, John, Richard ,  SHERBORNE, Brad ,  LITTLEWOOD, Peter Thomas Albert ,  BROWN, Angus Richard ,  KINGSBURY, Celia ,  OHLMEYER, Michael ,  HO, Koc-Kan ,  KULTGEN, Steven G.

IPC分类号： A61K31/18 ,  A61K31/4439 ,  C07C311/17 ,  C07D401/12

CPC分类号： C07C311/17 ,  C07C311/29 ,  C07D213/61 ,  C07D261/10 ,  C07D307/64 ,  C07D333/34 ,  C07D401/12

摘要： The invention provides for compounds having the structure according to the formula I wherein: X is a carbon or nitrogen atom; Ar is phenyl or heteroaromatic ring; R1 is hydrogen, halogen, CN or (1 C-4C)alkyl; R2 is hydrogen, halogen or optionally fluorinated (1 C-3C)alkoxy; R3 and R5 are independently hydrogen, optionally halogenated (1C- 4C)alkyl, optionally halogenated (1 C-4C)alkoxy, optionally halogenated aryl(1C-4C)alkoxy, optionally halogenated (1 C-4C)alkenyl or hydroxylmethyl; R4 is hydrogen, halogen, optionally halogenated (1 C-4C)alkoxy or optionally halogenated aryl(1 C-4C)alkoxy; R6 is hydrogen, benzyl, optionally substituted with one or more halogens or (1 C-4C)alkyl, or R6 is optionally halogenated (1 C-4C)alkyl; each R7 independently is hydrogen, halogen, optionally halogenated (1 C-4C)alkyl or optionally halogenated (1 C-4C)alkoxy and pharmaceutically suitable acid addition salts thereof for use as glucocorticoid receptor modulators, in particular for treatment of central nervous system disorders.